The prefrontal and orbital frontal cortex are consistently implicated in patients with OCD when studying the disorder through imaging or invasive electrode techniques. These regions are involved with compulsive behaviors such as washing or cleaning that are characteristic of OCD.
The prefrontal and orbital frontal cortex are areas of the frontal lobe consistently implicated in patients with Obsessive-Compulsive Disorder (OCD), causing hyper-checking behavior or contamination behavior, while rodent models may only exhibit aspects of OCD.