Chapter
MDMA's Mechanism of Action: Unlike Classic Psychedelics
07:02 - 24:04 (17:01)
MDMA does not mimic the endogenous neurotransmitter serotonin like classic psychedelics do. Instead, it works by throwing out more of the natural endogenous and affects the pitcher side.
Clips
The different types of psychedelic drugs are classified into pharmacological classes.
07:02 - 11:21 (04:18)
Summary
The different types of psychedelic drugs are classified into pharmacological classes. Classic psychedelics, which include LSD and psilocybin, and dissociative psychedelics, like ketamine and dextromethorphan, have different receptor effects that lead to behavioral and subjective effects.
ChapterMDMA's Mechanism of Action: Unlike Classic Psychedelics
EpisodeDr. Matthew Johnson: Psychedelics for Treating Mental Disorders
PodcastHuberman Lab
MDMA works on the pitcher side of the brain, leading to more release of natural endogenous neurotransmitters, while classic psychedelics work on the post-synaptic receptor side, mimicking serotonin.
11:21 - 19:47 (08:26)
Summary
MDMA works on the pitcher side of the brain, leading to more release of natural endogenous neurotransmitters, while classic psychedelics work on the post-synaptic receptor side, mimicking serotonin. Psychedelics affect the relationship of time and space via altering predictions, while the effects of smoked extracts are on par with those of DMT.
ChapterMDMA's Mechanism of Action: Unlike Classic Psychedelics
EpisodeDr. Matthew Johnson: Psychedelics for Treating Mental Disorders
PodcastHuberman Lab
This podcast discusses the profound effects of the serotonin system and dopamine system, which are neuromodulators responsible for changing the behavior of other circuits in the body.
19:47 - 22:22 (02:34)
Summary
This podcast discusses the profound effects of the serotonin system and dopamine system, which are neuromodulators responsible for changing the behavior of other circuits in the body. Specifically, it delves into how psychedelics such as LSD and psilocybin target the serotonin system and increase the activity of particular receptors, leading to challenging preexisting models and predictions.
ChapterMDMA's Mechanism of Action: Unlike Classic Psychedelics
EpisodeDr. Matthew Johnson: Psychedelics for Treating Mental Disorders
PodcastHuberman Lab
The speaker discusses how psychedelics and other drugs interface at the neuroscience level, including receptor level, downstream effects, neurotransmitters, and activation level effects.
22:22 - 24:04 (01:41)
Summary
The speaker discusses how psychedelics and other drugs interface at the neuroscience level, including receptor level, downstream effects, neurotransmitters, and activation level effects.