Chapter
Metformin and Rapamycin's Effect on Longevity
2:31:43 - 2:41:21 (09:37)
Dr. Satchin Panda discusses the similarities between the drug-like molecules Metformin and Rapamycin to the state of fasting and their potential effects on longevity when tested on humans in the long term.
Clips
Studies have shown that metformin and rapamycin, two drugs known for their potential to increase longevity, mimic certain aspects of the fasting state in mice by reducing M-tor activity and activating AMP kinase.
2:31:43 - 2:35:15 (03:32)
Summary
Studies have shown that metformin and rapamycin, two drugs known for their potential to increase longevity, mimic certain aspects of the fasting state in mice by reducing M-tor activity and activating AMP kinase. This has led to further investigation into the circadian aspects of these drugs' effects.
ChapterMetformin and Rapamycin's Effect on Longevity
EpisodeDr. Satchin Panda: Intermittent Fasting to Improve Health, Cognition & Longevity
PodcastHuberman Lab
Studies have shown that the effectiveness of metformin in reducing glucose levels in mice is highly dependent on the time at which it is administered, and it remains to be seen whether this applies to humans.
2:35:15 - 2:37:55 (02:39)
Summary
Studies have shown that the effectiveness of metformin in reducing glucose levels in mice is highly dependent on the time at which it is administered, and it remains to be seen whether this applies to humans. There is growing interest in the potential of metformin to trigger the fasting state, and experimentation with its administration time may yield promising results.
ChapterMetformin and Rapamycin's Effect on Longevity
EpisodeDr. Satchin Panda: Intermittent Fasting to Improve Health, Cognition & Longevity
PodcastHuberman Lab
Dr. Rhonda Patrick shares her experience with taking berberine and how it can affect blood glucose depending on whether or not it is ingested with carbohydrates.
2:37:55 - 2:39:05 (01:10)
Summary
Dr. Rhonda Patrick shares her experience with taking berberine and how it can affect blood glucose depending on whether or not it is ingested with carbohydrates. She warns of the potential for profound hypoglycemia if taken without consuming enough carbohydrates and discusses the benefits of taking berberine to help flatten out blood glucose response to sugary meals.
ChapterMetformin and Rapamycin's Effect on Longevity
EpisodeDr. Satchin Panda: Intermittent Fasting to Improve Health, Cognition & Longevity
PodcastHuberman Lab
Ron Evans explains the close relationship between circadian rhythm and metabolism and how almost all metabolic regulators have a diurnal cycle.
2:39:05 - 2:41:21 (02:15)
Summary
Ron Evans explains the close relationship between circadian rhythm and metabolism and how almost all metabolic regulators have a diurnal cycle. He also predicts the future popularity of circadian pills.