Chapter
Potential Mechanisms for Enhancing Antidepressant Effects
3:03:53 - 3:14:35 (10:42)
Researchers have found that a kappa opiate antagonism, which affects the reward circuit activation, reduces anhedonia in depressed patients, while the immunosuppressive effects of rapamycin are related to its ability to extend the antidepressant effects of ketamine.
Clips
Salvinorin A, an active compound found in the ethno-medical plant called Salvia divinorum, could potentially reduce anhedonia and affect reward circuit activity in depressed patients through kappa opiate antagonism.
3:03:53 - 3:06:41 (02:48)
Summary
Salvinorin A, an active compound found in the ethno-medical plant called Salvia divinorum, could potentially reduce anhedonia and affect reward circuit activity in depressed patients through kappa opiate antagonism. People often rate ketamine and psychedelic experiences as euphorogenic despite their varying levels of liking the experience.
ChapterPotential Mechanisms for Enhancing Antidepressant Effects
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Researchers are exploring the possibility of prolonging the short-duration antidepressant effects of ketamine, suggesting potential mechanisms causing the effectiveness to shorten.
3:06:41 - 3:09:35 (02:53)
Summary
Researchers are exploring the possibility of prolonging the short-duration antidepressant effects of ketamine, suggesting potential mechanisms causing the effectiveness to shorten. Patients currently progress from twice weekly to less frequent doses until ultimately finding relief every three to four weeks.
ChapterPotential Mechanisms for Enhancing Antidepressant Effects
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
The immunosuppressive effects of rapamycin may contribute to the antidepressant effects of ketamine, particularly in patients with treatment-resistant depression.
3:09:35 - 3:14:35 (05:00)
Summary
The immunosuppressive effects of rapamycin may contribute to the antidepressant effects of ketamine, particularly in patients with treatment-resistant depression. However, this theory is not supported in patients with post-traumatic stress disorder, where microglia suppression seems to be the critical component.