Chapter
Pushing Back Age-Related Decline
48:42 - 52:39 (03:56)
Researchers have found rapamycin and caloric restriction to be the most effective interventions to delay declines in functions and diseases. While they can proportionately extend health span, it's questioned whether they extend life or just delay decline, and much longer, human lifespans could make the magnitude of the effect even smaller.
Clips
The magnitude of effect of caloric restriction may not be as significant in humans due to their longer lifespan compared to mice and dogs.
48:42 - 50:01 (01:18)
Summary
The magnitude of effect of caloric restriction may not be as significant in humans due to their longer lifespan compared to mice and dogs. However, evidence suggests that caloric restriction can maintain function later in life in mice and potentially in humans.
ChapterPushing Back Age-Related Decline
Episode#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
PodcastThe Tim Ferriss Show
While there are interventions that extend lifespan in mice, none have convincingly extended the period of decline and poor health.
50:01 - 52:39 (02:37)
Summary
While there are interventions that extend lifespan in mice, none have convincingly extended the period of decline and poor health. The most effective interventions currently are rapamycin and caloric restriction, which have shown to push the declines in function and diseases back later into life.