Chapter
Rapamycin and Senescent Cells: The Key to Longevity?
21:29 - 27:13 (05:44)
Rapamycin, a drug currently used as an immunosuppressant, has shown potential in rejuvenating the immune system in mice. Additionally, senescent cells, which can cause an immune system hyperactivation, are being studied as a possible target for anti-aging therapies.
Clips
Rapamycin has been shown to rejuvenate aged immune systems, with just a six-week treatment, in mice causing it to function like a young immune system, and there's evidence this can happen in people too.
21:29 - 24:11 (02:41)
Summary
Rapamycin has been shown to rejuvenate aged immune systems, with just a six-week treatment, in mice causing it to function like a young immune system, and there's evidence this can happen in people too. As we age, our immune systems change, leading to chronic aches and pains, and sterile inflammation, which, to a degree, is a milder form of autoimmunity.
ChapterRapamycin and Senescent Cells: The Key to Longevity?
Episode#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
PodcastThe Tim Ferriss Show
Senolytics are molecules designed to kill dysfunctional senescent cells that produce harmful signals and activate the immune system.
24:11 - 27:13 (03:02)
Summary
Senolytics are molecules designed to kill dysfunctional senescent cells that produce harmful signals and activate the immune system. They are a promising approach to counteract aging and age-related diseases.