According to Manson's analyses, women who start taking hormones after age 60 have a small elevated risk of coronary heart disease, and a significant elevated risk if they start after age 70. Women who go through early menopause are recommended to take hormone therapy to avoid osteoporosis. The highest risk for hormone use are women who have already had heart attack, breast cancer, stroke, or blood clot, or women with a cluster of significant health problems.