The major risk of classic psychedelics is associated only with one or two percent of the population who have an active psychotic disorder. A rare condition called hallucinogen is also associated only with recreational use and typically with multiple drugs use including alcohol.
Psychedelics may offer a new approach to treating PTSD and enhancing relationships through their ability to increase empathy and emotional connection. Research shows promising results for reducing PTSD symptoms and strengthening relationships with the use of psychedelics.
Psilocybin has a remarkably low toxicity profile with no known lethal overdose or damage to organs. There is also no potential mechanism for neurotoxicity.
Psychedelics can cause challenging experiences, commonly known as bad trips, that may lead to dangerous behavior in a small minority of users. However, overall, they rank lowest in terms of public health risk compared to other major legal and illegal drugs.
The major risks associated with classic psychedelics are only applicable to a small percent of the population including those with psychotic predisposition or active psychotic disorders, while the chances of experiencing headaches post-use have also been documented.