Chapter
The Addiction Risk of Ketamine
2:25:56 - 2:42:45 (16:49)
Some programs that prescribe ketamine for depression exclude people with substance use disorders due to the addiction risks associated with ketamine, but limiting access to clinics can help protect patients from taking more than necessary or having it used recreationally. High doses of ketamine taken compulsively can increase vulnerability to depression rather than decreasing symptoms.
Clips
High doses of Ketamine taken frequently can increase a person's vulnerability to depression.
2:25:56 - 2:29:13 (03:17)
Summary
High doses of Ketamine taken frequently can increase a person's vulnerability to depression. Ketamine should be used with caution and respect, and programs that exclude people with substance use disorders may be limiting access to an effective antidepressant.
ChapterThe Addiction Risk of Ketamine
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Freedom Biosciences is developing a version of ketamine that has reduced abuse risk associated with it.
2:29:13 - 2:32:26 (03:12)
Summary
Freedom Biosciences is developing a version of ketamine that has reduced abuse risk associated with it. Limiting the availability of ketamine to the clinical setting is an important step to protect people from taking excessive amounts and to limit the possibility of diversion to others for recreational purposes.
ChapterThe Addiction Risk of Ketamine
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Researchers are studying the potential of R-ketamine, the mirror image of S-ketamine, as an alternative with less abuse liability.
2:32:26 - 2:38:43 (06:17)
Summary
Researchers are studying the potential of R-ketamine, the mirror image of S-ketamine, as an alternative with less abuse liability. Strategies are being developed to reduce the risk of addiction associated with ketamine.
ChapterThe Addiction Risk of Ketamine
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
There are two versions of ketamine, R and S, with S ketamine being more potent at blocking the NMDA glutamate receptor, which has led to pharmaceutical companies developing alternatives to ketamine that target just the subtype of the NMDA glutamate receptor to block.
2:38:43 - 2:42:45 (04:01)
Summary
There are two versions of ketamine, R and S, with S ketamine being more potent at blocking the NMDA glutamate receptor, which has led to pharmaceutical companies developing alternatives to ketamine that target just the subtype of the NMDA glutamate receptor to block.