Chapter
The Effects of Metformin on the Respiratory Chain
54:47 - 57:33 (02:46)
The use of metformin may indirectly inhibit the respiratory chain, but there is limited research on the topic.
Clips
The mechanisms of action for rapamycin and metformin are different.
54:47 - 55:25 (00:38)
Summary
The mechanisms of action for rapamycin and metformin are different. While rapamycin directly inhibits mTOR, metformin indirectly inhibits it by inhibiting the respiratory chain.
ChapterThe Effects of Metformin on the Respiratory Chain
Episode#193: My Life Extension Pilgrimage to Easter Island
PodcastThe Tim Ferriss Show
Metformin is popular as it is used to reduce cancer rates on diabetics, however, there are assumptions that need to be validated such as its effects as a pro-lifespan agent and if it is beneficial for all tissues of the body.
55:25 - 56:47 (01:22)
Summary
Metformin is popular as it is used to reduce cancer rates on diabetics, however, there are assumptions that need to be validated such as its effects as a pro-lifespan agent and if it is beneficial for all tissues of the body. There are cohort studies that show differences between patients taking and not taking Metformin, but randomized controlled trials are needed.
ChapterThe Effects of Metformin on the Respiratory Chain
Episode#193: My Life Extension Pilgrimage to Easter Island
PodcastThe Tim Ferriss Show
Lifestyle changes such as reducing alcohol consumption, not smoking, maintaining a healthy weight, and regular exercise can lead to a 15-20% reduction in the incidence of cancer and a 20-30% reduction in mortality or extension of survival once diagnosed with cancer.
56:47 - 57:33 (00:46)
Summary
Lifestyle changes such as reducing alcohol consumption, not smoking, maintaining a healthy weight, and regular exercise can lead to a 15-20% reduction in the incidence of cancer and a 20-30% reduction in mortality or extension of survival once diagnosed with cancer.