Chapter

The History of Early Vaccine Trials
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1:34:04 - 1:41:54 (07:49)

This podcast covers the history of the first influenza vaccines developed by Jonas Salk in the 1940s and the process of vaccine trials. It also discusses cultural attitudes towards feeling sick and the idea of "toughing up".

Clips
The process of making vaccines involves growing lots of virus in chicken eggs, as was done with the influenza vaccine in the 1940s by Jonas Salk.
1:35:29 - 1:37:00 (01:30)
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Vaccines
Summary

The process of making vaccines involves growing lots of virus in chicken eggs, as was done with the influenza vaccine in the 1940s by Jonas Salk. However, even with a perfect vaccine, some people still choose not to get vaccinated.

Chapter
The History of Early Vaccine Trials
Episode
#216 – Vincent Racaniello: Viruses and Vaccines
Podcast
Lex Fridman Podcast
Inactivated flu vaccines, which are based on chemical inactivation of the virus, are easy to produce but present limitations in effectively training the immune system against the actual virus.
1:37:00 - 1:39:18 (02:18)
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Inactivated Flu Vaccines
Summary

Inactivated flu vaccines, which are based on chemical inactivation of the virus, are easy to produce but present limitations in effectively training the immune system against the actual virus. This method is often referred to as "old-school" and is considered inferior to other vaccine production methods.

Chapter
The History of Early Vaccine Trials
Episode
#216 – Vincent Racaniello: Viruses and Vaccines
Podcast
Lex Fridman Podcast
The cultural perception of reporting symptoms has changed and now people are more likely to report symptoms during vaccine trials.
1:39:18 - 1:41:54 (02:35)
listen on Spotify
Vaccine Trials
Summary

The cultural perception of reporting symptoms has changed and now people are more likely to report symptoms during vaccine trials. This is important as it can affect the accuracy of trials and the effectiveness of the vaccine.

Chapter
The History of Early Vaccine Trials
Episode
#216 – Vincent Racaniello: Viruses and Vaccines
Podcast
Lex Fridman Podcast