Chapter
The Link Between Genetics, Immune Function, and Disease
1:12:25 - 1:20:31 (08:06)
Genetic variation in blood types and immune function cells can increase the likelihood of death from contracting a virus. The human genome has evolved to co-opt immune genes for non-immune functions.
Clips
Despite repeated outbreaks of pandemics, humans have never been fully wiped out.
1:12:25 - 1:13:09 (00:44)
Summary
Despite repeated outbreaks of pandemics, humans have never been fully wiped out. While human life is invaluable, the survival of the species is not under threat.
ChapterThe Link Between Genetics, Immune Function, and Disease
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
Genetic associations with human diseases show the effects of past waves of selection against diseases.
1:13:09 - 1:16:17 (03:08)
Summary
Genetic associations with human diseases show the effects of past waves of selection against diseases. Immune genes that have evolved to combat diseases have been co-opted to carry out other functions in the body.
ChapterThe Link Between Genetics, Immune Function, and Disease
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
Genetic variations can play a significant role in determining who is more susceptible to diseases, including obesity, and how a population adapts to new environments or pandemics.
1:16:17 - 1:18:36 (02:18)
Summary
Genetic variations can play a significant role in determining who is more susceptible to diseases, including obesity, and how a population adapts to new environments or pandemics. The FTO locus, for example, can increase the likelihood of an individual becoming obese.
ChapterThe Link Between Genetics, Immune Function, and Disease
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
The immune system relies on diversity in order to create a broad range of repertoires to fight off pathogens.
1:18:36 - 1:20:31 (01:54)
Summary
The immune system relies on diversity in order to create a broad range of repertoires to fight off pathogens. This diversity comes from the selection for VDJ recombination and the layers of diversity within the immune system itself.