Chapter
The Overlap Between Ketamine and Rapamycin
3:14:35 - 3:29:48 (15:13)
This episode explores the similarities between ketamine and rapamycin and their effects on glutamate release and mTOR activation, as well as the aim to trigger cellular self-repair through mTOR modulation without triggering immunosuppression.
Clips
In this episode, the link between stress-related disorders and major depression is explored, along with the explanation of how the antidepressant effects of ketamine work by preventing microglia from absorbing newly created synapses.
3:14:35 - 3:16:35 (01:59)
Summary
In this episode, the link between stress-related disorders and major depression is explored, along with the explanation of how the antidepressant effects of ketamine work by preventing microglia from absorbing newly created synapses. A version of this treatment is being developed by Freedom Biosciences for use in the treatment environment.
ChapterThe Overlap Between Ketamine and Rapamycin
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
This episode explores the use of ketamine and rapamycin to trigger specific effects on mTORS, initiating autophagy, cellular cleaning, and repair, without the risk of immunosuppressant effects or infection.
3:16:35 - 3:22:38 (06:03)
Summary
This episode explores the use of ketamine and rapamycin to trigger specific effects on mTORS, initiating autophagy, cellular cleaning, and repair, without the risk of immunosuppressant effects or infection. The combination of these two drugs also has the potential to last longer when repeated.
ChapterThe Overlap Between Ketamine and Rapamycin
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Ketamine therapy has the potential to increase treatment tolerance, reduce costs, and improve patient access to treatment.
3:22:38 - 3:24:32 (01:54)
Summary
Ketamine therapy has the potential to increase treatment tolerance, reduce costs, and improve patient access to treatment. Higher doses of ketamine can produce psychedelic effects, making it a more versatile compound than MDMA.
ChapterThe Overlap Between Ketamine and Rapamycin
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Ketamine and other psychedelics have similar effects such as the release of glutamate, activation of mTOR, and the stimulation of thalamic neuronal activity which results in the increase of excitability, triggering the downstream neurotrophic effects and regrowth of lost synapses in animal models.
3:24:32 - 3:29:48 (05:16)
Summary
Ketamine and other psychedelics have similar effects such as the release of glutamate, activation of mTOR, and the stimulation of thalamic neuronal activity which results in the increase of excitability, triggering the downstream neurotrophic effects and regrowth of lost synapses in animal models.