Chapter
The Relationship Between Aging and Fat, and How to Tackle It
1:49:21 - 1:54:52 (05:31)
Dr. David Sinclair talks about the relationship between fat and aging, and how killing off senescent cells (cells that are functionally alive but do not divide and accumulate with age) can reduce toxicity of fat. Additionally, he discusses how activating genes such as SIRT1 and SIRT2 and inhibiting inflammation in the hypothalamus through controlling hormones like GNRH can lead to extending the lifespan.
Clips
Senescent cells in fat lead to inflammation and accelerate aging, but inhibiting inflammation in the hypothalamus can better treat the disease.
1:49:21 - 1:53:17 (03:56)
Summary
Senescent cells in fat lead to inflammation and accelerate aging, but inhibiting inflammation in the hypothalamus can better treat the disease. Activating sirtuins and maintaining GnRH hormone expression also contributes to extending lifespan.
ChapterThe Relationship Between Aging and Fat, and How to Tackle It
EpisodeDr. David Sinclair: The Biology of Slowing & Reversing Aging
PodcastHuberman Lab
The use of Methylene Blue in experiments has been researched by scientists to extend lifespans in lower organisms.
1:53:17 - 1:54:52 (01:34)
Summary
The use of Methylene Blue in experiments has been researched by scientists to extend lifespans in lower organisms. Despite its unusual effects, scientists use it for various experiments including the study of the blood-brain barrier.