The relationship between adenosine and adenosine receptors, as well as genetic variations, make it hard to determine if and when one should consume caffeine. However, some individuals with a mutant form of the adenosine receptor can drink caffeine late in the evening and still fall asleep easily.
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The impact of caffeine on sleep depends on personal tolerance and genetic variations among individuals. While caffeine has health benefits, it can also have problematic effects such as raising blood pressure. It increases dopamine, which is related to energy and motivation, and helps us stay awake.
The effects of caffeine on sleep vary among individuals. Science suggests that genetics and the build-up of adenosine can both play a role in this.