Chapter

The Role of Estrogen in Masculinizing the Brain
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28:21 - 39:13 (10:51)

Contrary to popular belief, estrogen and not testosterone or dihydrotestosterone, that comes from testosterone, masculinizes the male brain. The neurons in the brain that make aromatase convert testosterone into estrogen, thereby masculinizing the male brain.

Clips
Although cells in the brain have receptors for testosterone, the masculinization of the brain is not achieved by the hormone.
28:21 - 33:26 (05:04)
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Testosterone
Summary

Although cells in the brain have receptors for testosterone, the masculinization of the brain is not achieved by the hormone. Instead, it is dihydrotestosterone that is responsible for the growth of the penis, and later testosterone is involved in secondary characteristics.

Chapter
The Role of Estrogen in Masculinizing the Brain
Episode
The Science of Sexual Development
Podcast
Huberman Lab
In this podcast episode, the speaker explains how estrogen, not testosterone, masculinizes the male brain, and how aromatase converts testosterone to estrogen.
33:26 - 35:12 (01:46)
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Aromatase
Summary

In this podcast episode, the speaker explains how estrogen, not testosterone, masculinizes the male brain, and how aromatase converts testosterone to estrogen. The episode also touches upon gynecomastia, the development of male breast tissue due to the conversion of testosterone to estrogen.

Chapter
The Role of Estrogen in Masculinizing the Brain
Episode
The Science of Sexual Development
Podcast
Huberman Lab
Evening primrose oil contains estrogenic compounds that can promote estrogenic pathways in the body.
35:12 - 39:13 (04:00)
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Evening Primrose Oil
Summary

Evening primrose oil contains estrogenic compounds that can promote estrogenic pathways in the body. Some young boys have experienced accelerated breast development from skin contact with women who use this oil.

Chapter
The Role of Estrogen in Masculinizing the Brain
Episode
The Science of Sexual Development
Podcast
Huberman Lab