Chapter

The Science Behind Caffeine's Effects on the Brain
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52:15 - 1:01:09 (08:53)

Caffeine works by latching onto adenosine receptors in the brain, blocking the communication of adenosine which tells the brain how long the body has been awake. This creates a feeling of alertness, but once the caffeine wears off, the body is hit with a surge of adenosine that has been building up, leading to the feeling of a "crash".

Clips
Adenosine is a chemical that accumulates in the brain throughout the day, inhibiting wake-promoting areas while increasing the promotion of sleep, explaining the feeling of sleepiness after staying awake for extended periods.
52:15 - 55:50 (03:35)
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Adenosine
Summary

Adenosine is a chemical that accumulates in the brain throughout the day, inhibiting wake-promoting areas while increasing the promotion of sleep, explaining the feeling of sleepiness after staying awake for extended periods.

Chapter
The Science Behind Caffeine's Effects on the Brain
Episode
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep
Podcast
Huberman Lab
The speaker muses on the connection between sleep and conversations, wondering if people's sleep history has an impact on whether they find certain conversations engaging or not.
55:50 - 56:19 (00:28)
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Sleep
Summary

The speaker muses on the connection between sleep and conversations, wondering if people's sleep history has an impact on whether they find certain conversations engaging or not.

Chapter
The Science Behind Caffeine's Effects on the Brain
Episode
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep
Podcast
Huberman Lab
Caffeine blocks the brain's adenosine receptors, which would otherwise communicate to the brain that you've been awake for a long time and create a feeling of sleepiness.
56:19 - 59:45 (03:26)
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caffeine
Summary

Caffeine blocks the brain's adenosine receptors, which would otherwise communicate to the brain that you've been awake for a long time and create a feeling of sleepiness. The speed at which the liver breaks down caffeine can affect an individual's sensitivity to it.

Chapter
The Science Behind Caffeine's Effects on the Brain
Episode
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep
Podcast
Huberman Lab
After consuming caffeine, adenosine continues to build up in our system, which can lead to increased levels of fatigue once the caffeine wears off.
59:45 - 1:01:09 (01:23)
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Caffeine
Summary

After consuming caffeine, adenosine continues to build up in our system, which can lead to increased levels of fatigue once the caffeine wears off. Caffeine can also trick our brain into thinking we have not been awake for as long as we actually have.

Chapter
The Science Behind Caffeine's Effects on the Brain
Episode
Dr. Matthew Walker: The Science & Practice of Perfecting Your Sleep
Podcast
Huberman Lab