Chapter
The Science of Ketones and Keto Diets
21:21 - 33:10 (11:48)
The guest explains how prolonged fasting leads to the body breaking down its own sources of fat, producing beta hydroxybutyrate and acetoacetate, which become substrates for making ATP and are utilized by the brain as fuel, leading to weight loss and cognitive benefits.
Clips
Our bodies start breaking down sources of fat after prolonged fasting, producing beta hydroxybutyrate and acetoacetate, which become another substrate for making ATP in the Krebs cycle, providing energy to the brain.
21:21 - 25:29 (04:07)
Summary
Our bodies start breaking down sources of fat after prolonged fasting, producing beta hydroxybutyrate and acetoacetate, which become another substrate for making ATP in the Krebs cycle, providing energy to the brain. This is a crucial adaptation since the human body has evolved to store a finite amount of glucose, leading to an organism that is wildly dependent on glucose and can only store about one day's worth.
ChapterThe Science of Ketones and Keto Diets
EpisodeEp 50: Dr. Peter Attia on Ultra-Endurance, Drinking Jet Fuel, Human Foie Gras, and More
PodcastThe Tim Ferriss Show
A cyclist shares his experience with trying out different performance enhancing supplements, including ketone esters, which he describes as the worst tasting thing he has ever had, and his determination to find a way to make it work.
25:29 - 30:52 (05:23)
Summary
A cyclist shares his experience with trying out different performance enhancing supplements, including ketone esters, which he describes as the worst tasting thing he has ever had, and his determination to find a way to make it work.
ChapterThe Science of Ketones and Keto Diets
EpisodeEp 50: Dr. Peter Attia on Ultra-Endurance, Drinking Jet Fuel, Human Foie Gras, and More
PodcastThe Tim Ferriss Show
Researchers have shown that switching the substrate from glucose or fatty acid to ketones can generate more mechanical work for less oxygen in animal models, leading to potential benefits in athletic endurance events.
30:52 - 33:10 (02:17)
Summary
Researchers have shown that switching the substrate from glucose or fatty acid to ketones can generate more mechanical work for less oxygen in animal models, leading to potential benefits in athletic endurance events.