Chapter
The Three Major Chemical Systems in the Brain Related to Depression
32:30 - 39:01 (06:31)
Understanding the three major chemical systems in the brain - norepinephrine, dopamine, and serotonin and how they affect depression symptoms can help in using selective serotonin reuptake inhibitors (SSRIs) to increase the efficacy of serotonin in the brain synapse.
Clips
SSRIs increase the efficiency of serotonin at the synapse, preventing it from being wiped up from the synapse between two neurons.
32:30 - 36:12 (03:42)
SSRIs
Summary
SSRIs increase the efficiency of serotonin at the synapse, preventing it from being wiped up from the synapse between two neurons. They don't increase serotonin levels, Prozac and Zoloft are examples of SSRIs.
ChapterThe Three Major Chemical Systems in the Brain Related to Depression
EpisodeUnderstanding & Conquering Depression
PodcastHuberman Lab
The norepinephrine, dopamine, and serotonin systems are related to activity/alertness, motivation/pleasure, and grief, respectively.
36:12 - 39:01 (02:48)
Depression
Summary
The norepinephrine, dopamine, and serotonin systems are related to activity/alertness, motivation/pleasure, and grief, respectively. Lack of dopamine in depressive patients can lead to anhedonia, and fluoxetine can increase neurogenesis and alleviate depressive symptoms.