Chapter
Understanding Evolutionary Dynamics in the Genome
1:46:05 - 1:54:17 (08:11)
The speaker discusses how studying the evolutionary dynamics of the present genome can help us understand which mutations have occurred previously, how they impact rapidly-evolving genes, and how evolution can lead to a new optimum by allowing mutations both to create new functions and break old ones.
Clips
By studying the evolutionary dynamics of the current COVID-19 genome, researchers can understand which mutations have occurred and which genes evolve most rapidly.
1:46:05 - 1:47:55 (01:49)
Summary
By studying the evolutionary dynamics of the current COVID-19 genome, researchers can understand which mutations have occurred and which genes evolve most rapidly. For example, the D614 gene mutation, which is widely discussed in the news, disrupts a unique nucleotide position conserved throughout the evolution of equivalent mammalian viruses.
ChapterUnderstanding Evolutionary Dynamics in the Genome
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
COVID-19 virus has mutated, replacing an amino acid, making it easier to transmit from human to human.
1:47:55 - 1:49:55 (01:59)
Summary
COVID-19 virus has mutated, replacing an amino acid, making it easier to transmit from human to human. This new version is well suited for human transmission as compared to bat transmission.
ChapterUnderstanding Evolutionary Dynamics in the Genome
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
Building resilient systems that allow for failure and can reach a new optimum.
1:49:55 - 1:52:18 (02:23)
Summary
Building resilient systems that allow for failure and can reach a new optimum. Designing new paradigms focused more on getting the right answer most of the time, rather than all of the time.
ChapterUnderstanding Evolutionary Dynamics in the Genome
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
The human brain, with its trillions of connections, millions of cells, and specialized blood supply, is still encoded within the same genome as the rest of the body, highlighting the complexity of our genetic blueprint.
1:52:18 - 1:54:17 (01:59)
Summary
The human brain, with its trillions of connections, millions of cells, and specialized blood supply, is still encoded within the same genome as the rest of the body, highlighting the complexity of our genetic blueprint.