Chapter
Understanding the Differences Between Ketamine and Psilocybin for Treating Depression
1:28:33 - 1:42:27 (13:54)
Ketamine and PCP both suppress the NMDA receptor and treat depression by removal of negative experiences, while psilocybin focuses more on the rewiring of circuitry in the brain to help treat depression, but the effects on patients vary.
Clips
Neurons in the prefrontal cortex have spiny protrusions where they can form and receive synapses from neighboring neurons.
1:28:33 - 1:30:37 (02:03)
Summary
Neurons in the prefrontal cortex have spiny protrusions where they can form and receive synapses from neighboring neurons. Ketamine can relieve depressive symptoms by increasing the number of spines on these neurons.
ChapterUnderstanding the Differences Between Ketamine and Psilocybin for Treating Depression
EpisodeUnderstanding & Conquering Depression
PodcastHuberman Lab
Ketamine therapy helps severely depressed people to distance themselves from the negative affect that they feel is them and disrupts the patterns of guilt, grief and anti-self confabulations, which can lead to extreme cases of self-harm and suicide.
1:30:37 - 1:33:01 (02:24)
Summary
Ketamine therapy helps severely depressed people to distance themselves from the negative affect that they feel is them and disrupts the patterns of guilt, grief and anti-self confabulations, which can lead to extreme cases of self-harm and suicide. This approach offers a promising alternative to traditional treatments and could break the cycle of negative thinking that characterizes major depression.
ChapterUnderstanding the Differences Between Ketamine and Psilocybin for Treating Depression
EpisodeUnderstanding & Conquering Depression
PodcastHuberman Lab
Ketamine and PCP may suppress the activity of the NMDA receptor and induce neuroplasticity circuit changes as a way to treat depression, particularly in severe cases.
1:33:01 - 1:38:37 (05:35)
Summary
Ketamine and PCP may suppress the activity of the NMDA receptor and induce neuroplasticity circuit changes as a way to treat depression, particularly in severe cases. These compounds have shown exciting therapeutic outcomes and potential for reducing the experience of negative emotions.
ChapterUnderstanding the Differences Between Ketamine and Psilocybin for Treating Depression
EpisodeUnderstanding & Conquering Depression
PodcastHuberman Lab
A recent study showed that between 50 to 70% of individuals experienced significant improvement in mood and relief from depressive symptoms after undergoing psilocybin treatment, despite the subjective and varied nature of their experiences.
1:38:37 - 1:42:27 (03:50)
Summary
A recent study showed that between 50 to 70% of individuals experienced significant improvement in mood and relief from depressive symptoms after undergoing psilocybin treatment, despite the subjective and varied nature of their experiences. The role of the experience itself in bringing relief from depression remains a fundamental question that requires further exploration.