THC and CBD bind to our naturally created cannabinoid receptors with much greater potency and effect than our endogenous cannabinoids, causing biological effects on mood, perception, the immune system, hunger, and more. Even if we never go near the cannabis plant, we have natural chemicals that park in these receptors, leading to biological effects.
While cannabis may have therapeutic benefits, high THC concentration cannabis can increase the probability of psychotic episodes, particularly in young males in their early teens and 20s. It is not as harmless as some proponents suggest and can lead to chronic short-term health issues.
Nicotine, because it can pass through the blood-brain barrier has rapid effects on the brain, particularly on the mesolimbic reward pathway or the dopamine reward pathway, which can trigger the release of certain neurochemicals from the ventral tegmental area and impinge on nucleus accumbens to increase dopamine levels.
This podcast episode provides a brief but informative overview of psychedelics, including the different types and how they differ from one another, such as in their pharmacological pathways and subjective effects. The safety of some of the more commonly discussed psychedelics is also touched upon.
The different types of psychedelic drugs are classified into pharmacological classes. Classic psychedelics, which include LSD and psilocybin, and dissociative psychedelics, like ketamine and dextromethorphan, have different receptor effects that lead to behavioral and subjective effects.
Chronic use of cannabis, defined as using it twice a week or more, can lead to increased levels of anxiety over time, according to research. Although there may be positive effects on mood, anxiety, and pain relief, it's important to have an informed discussion about the potential negative consequences of cannabis use.