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The Effects of THC and CBD on our Endocannabinoid System
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26:33 - 29:25 (02:52)

THC and CBD bind to our naturally created cannabinoid receptors with much greater potency and effect than our endogenous cannabinoids, causing biological effects on mood, perception, the immune system, hunger, and more. Even if we never go near the cannabis plant, we have natural chemicals that park in these receptors, leading to biological effects.

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Nicotinic receptors
Summary

Nicotinic receptors are a type of acetylcholine receptor found in the brain and body that are activated by the chemical nicotine, leading to changes in cell behavior and increased activity.

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Nicotine, because it can pass through the blood-brain barrier has rapid effects on the brain, particularly on the mesolimbic reward pathway or the dopamine reward pathway, which can trigger the release of certain neurochemicals from the ventral tegmental area and impinge on nucleus accumbens to increase dopamine levels.

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