The interactions between mitochondrial DNA and genes in the nucleus are often disregarded due to the lack of attention given to mitochondrial genes. Mitochondrial DNA controls energy and biosynthesis functions, and cancer cells rewire mitochondria to use them as components for biosynthesis instead of energy creation.
There is a lot of money being invested into longevity studies, but taking care of oneself can prolong lifespan and maintain health span. The last segment of one's life can be spent in a declining state if proper care is not taken.
The hosts discuss their thoughts on the origins of the universe and whether humans are a good or bad thing for it.
Multicellular organisms learned to use oxygen for energy 500 million years ago after algae figured out how to convert sunlight into energy. The result was the development of aerobic metabolism, which remains the most efficient way to use energy today.
Peter Attia talks about the future of medicine, including the potential of gene therapy, immunotherapy, and regenerative medicine to replace current treatments. He also touches on the protective effects of fasting, particularly when combined with chemotherapy and radiation for cancer.
Synthetic biologist Jason Chin introduces the concept of designer cells; modules that tokenize genes and redesign entire genomes using a "find and replace" feature for a targeted purpose.