John F. Crowley is the Chairman and CEO of Amicus Therapeutics, a publicly traded biotechnology company, which he helped to found in 2005 and is now a 300+ person company in 22 countries. John's involvement with biotechnology stems from the 1998 diagnosis of two of his children with Pompe disease -- a severe and often fatal neuromuscular disorder. In his drive to find a cure for them, he left his job and became an entrepreneur as the Co-founder, President, and CEO of Novazyme Pharmaceuticals in 2000, a biotech start-up conducting research on a new experimental treatment for Pompe disease (which he credits as ultimately saving his children's lives). In 2001, Novazyme was acquired by Genzyme Corporation for nearly $200 million. John and his family have been profiled on the front page of The Wall Street Journal and are the subjects of a book by Pulitzer prize-winning journalist Geeta Anand, The Cure: How a Father Raised $100 Million -- and Bucked the Medical Establishment -- in a Quest to Save His Children. The major motion picture Extraordinary Measures, starring Brendan Fraser and Harrison Ford, is inspired by the Crowley family journey. John is the author of a personal memoir: Chasing Miracles: The Crowley Family Journey of Strength, Hope, and Joy. John also served as a commissioned intelligence officer in the U.S. Navy Reserve from 2005-2016. He was assigned to the Joint Special Operations Command (JSOC) and is a veteran of the global war on terrorism, with service in Afghanistan. He graduated with a B.S. in Foreign Service from Georgetown University, and earned a J.D. from the University of Notre Dame Law School and an M.B.A. from Harvard. He previously served (2014-2016) as the National Chairman of the Make-A-Wish Foundation of America and is a founding board member of the Global Genes Project. John is a Henry Crown Fellow at The Aspen Institute. This is an incredibly powerful episode. Enjoy! Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by iD Commerce + Logistics. I'm asked all the time about how to scale businesses quickly. Rule number one: remove unnecessary bottlenecks. Many businesses can do so by outsourcing inventory management and fulfillment to a company that makes this its primary focus. iD Commerce + Logistics is just such a company. It helps online retailers and entrepreneurs outgrow their competition by handling all types of details -- from inventory to packing and shipping. I depended on iD to handle these types of details when I launched The 4-Hour Chef so I could focus on promoting the book. 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Entrepreneur and musician Derek Sivers shares his thoughts on finding happiness, developing confidence, and learning how to say "no" in this episode. He also talks about how he turned down millions of dollars for a company he co-founded and why he did it.
John Crowley, co-founder and President of Novazheim Pharmaceuticals, discusses his journey from leaving his job to become an entrepreneur, to ultimately saving his children's lives and serving as an intelligence officer in the U.S. Navy Reserve.
The guest speaker discusses his childhood experiences, particularly dealing with the death of his father in 1975 and how he learned early on in life to study as a road to success.
The guest talks about how he made the tough decision to voluntarily resign from the Naval Academy and attend Georgetown's School of Foreign Service instead. He also discusses the impact of his football coaches and Christian Brothers mentors in high school.
Speaker shares his personal experience of the Notre Dame education and its emphasis on understanding businesses through the case study method. He also talks about how the decision to move to Boston to attend Notre Dame was one of the best decisions they made.
The case study called "A Father's Love" covers the journey of a family whose child was diagnosed with a rare genetic disorder, and how the father navigated his career and personal life while being a caregiver to his child.
This podcast episode tells the story of John Crowley, a father who quit his job to focus on finding a cure for his children who were diagnosed with Pompe disease. He founded a biotech company, raised money from not-for-profit organizations, and eventually sold the company to Genzyme after discovering a treatment for the rare disorder.
John Crowley talks about the challenges he faced in developing a drug that could save his children from Pompe disease, including the difficulties in getting them treated and the desperation he felt at times.
John Crowley, CEO of Amicus Therapeutics, talks about the remarkable resilience of children with special needs and rare diseases. He also shares how his family’s experience inspired him to found the biotech company and find next-generation therapies for these conditions.
Megan's parents were the ones who had the problem.
The economic challenge of developing a small range of drugs for diseases that only affect a limited number of individuals has started to be overcome with new technologies and faster manufacturing methods. Amicus was created to provide a caring and slow response to the needs of patients with rare diseases.
The biotech industry was founded only 41 years ago in San Francisco by venture capitalist Bob Swanson and UCSF professor Herb Boyer in 1976. To develop resilience, one must build character through trial and adversity, which can be done through activities that require sacrifice or rigorous physical training.
John Crowley emphasizes the importance of time in life and how medicine can offer more of it. The innovation in medicine that focuses on extending the time and improving the quality of life gives a chance for more quality time with family and loved ones.
The Make-A-Wish Foundation started with a seven-year-old boy named Chris who had advanced leukemia and wanted to be a cop, and with the help of some police officers, they made his dream come true. The foundation has now granted over a quarter of a million wishes to children with life-threatening illnesses, bringing joy not only to them but also to their communities, and its success shows that one person's desire to help can have a huge and lasting impact in the world of rare diseases.
John Crowley, CEO of Amicus Therapeutics, shares a typical day in his life, including waking up at 6 am, catching up on emails and the news while exercising on the elliptical, spending time with the team, and getting in an evening workout in his basement.
Tim Ferriss discusses his "Five Bullet Friday" newsletter where he shares his favorite discoveries, including music, gadgets, articles, and more, with subscribers. He encourages listeners to sign up on his website.