Chapter
Determining the Magnitude of Difference in Effect Sizes
59:55 - 1:07:18 (07:23)
Understanding the magnitude of difference in effect sizes is important to determine the number of subjects needed to recruit for a study. It's also essential to open up state and federal funding for this type of research from NIMH, NIH, etc.
Clips
In order to determine the number of subjects required for a clinical trial, it is important to correctly speculate the magnitude of difference in effect sizes between treatment A and treatment B.
59:55 - 1:02:29 (02:34)
Summary
In order to determine the number of subjects required for a clinical trial, it is important to correctly speculate the magnitude of difference in effect sizes between treatment A and treatment B. This can be achieved by referencing a complicated table that outlines different effect sizes based on the expected outcome.
ChapterDetermining the Magnitude of Difference in Effect Sizes
Episode#517: Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and the 3 Most Important Levers to Pull
PodcastThe Tim Ferriss Show
The goal of non-inferiority trials is to compare a new drug to a pre-existing one and prove that it is not worse, and potentially better.
1:02:30 - 1:04:55 (02:24)
Summary
The goal of non-inferiority trials is to compare a new drug to a pre-existing one and prove that it is not worse, and potentially better. A two and a half point increase may be clinically relevant and enough to advance clinical utilization and promulgate further studies.
ChapterDetermining the Magnitude of Difference in Effect Sizes
Episode#517: Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and the 3 Most Important Levers to Pull
PodcastThe Tim Ferriss Show
The choice of primary outcome measure in research studies can be crucial in determining the success and impact of the study.
1:04:55 - 1:07:18 (02:23)
Summary
The choice of primary outcome measure in research studies can be crucial in determining the success and impact of the study. It's also important to secure funding for this type of research to advance scientific understanding.