Chapter
Genome Editing and the Causes of Obesity
1:50:10 - 1:55:18 (05:08)
Scientists have discovered a new way to control obesity by genome editing using CRISPR-Cas9 technology; by changing one nucleotide out of billions in the human genome, scientists could switch the phenotype of a person from obese to lean. The decision to make beige fat (energy burning) or white fat (energy storing) can be made during adipocyte differentiation.
Clips
Using CRISPR-Cas9 editing, researchers found that by editing one single nucleotide, they could switch between an obese and lean phenotype in primary adipocytes, showing the potential for intervention in the differentiation stage in creating either the white fat or beige fat.
1:50:10 - 1:53:17 (03:07)
Summary
Using CRISPR-Cas9 editing, researchers found that by editing one single nucleotide, they could switch between an obese and lean phenotype in primary adipocytes, showing the potential for intervention in the differentiation stage in creating either the white fat or beige fat.
ChapterGenome Editing and the Causes of Obesity
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The advancements in technology and knowledge over the years have allowed for systematic research on thousands of loci in the human genome, enabling scientists to identify one nucleotide's effect and make progress in understanding genomes.
1:53:17 - 1:55:18 (02:00)
Summary
The advancements in technology and knowledge over the years have allowed for systematic research on thousands of loci in the human genome, enabling scientists to identify one nucleotide's effect and make progress in understanding genomes.