Chapter
How Ketamine Works as an Antidepressant
55:55 - 1:16:12 (20:16)
The activation of mTOR, or the mechanistic target of rapamycin, through nerve growth factors such as BDNF leads to the regeneration and stabilization of synaptic connections in the brain, which explains how ketamine works as an antidepressant. The use of ketamine as an antidepressant was hypothesized after observing its effectiveness in treating pain and as a result of rumors that veterans who received it experienced less PTSD.
Clips
Researchers have found evidence that prolonged stress leads to a loss of synaptic connections in the brain, contributing to behavioural and cognitive changes, and the development of depression.
55:55 - 1:01:46 (05:50)
Summary
Researchers have found evidence that prolonged stress leads to a loss of synaptic connections in the brain, contributing to behavioural and cognitive changes, and the development of depression. However, giving a dose of ketamine to stressed animals can produce rapid biochemical, electrophysiological, and structural changes in the brain in just 24 hours, according to researchers George Agajanian and Ron Dumon.
ChapterHow Ketamine Works as an Antidepressant
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
This podcast episode explores the history and potential therapeutic benefits of ketamine, a dissociative anesthetic that has been shown to help with depression and other mental health conditions.
1:01:46 - 1:06:01 (04:15)
Summary
This podcast episode explores the history and potential therapeutic benefits of ketamine, a dissociative anesthetic that has been shown to help with depression and other mental health conditions.
ChapterHow Ketamine Works as an Antidepressant
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
This podcast discusses the molecular signaling mechanisms and growth factors involved in the use of ketamine for the treatment of depression, as described by a psychiatric researcher specializing in depression and anxiety disorders.
1:06:01 - 1:11:59 (05:57)
Summary
This podcast discusses the molecular signaling mechanisms and growth factors involved in the use of ketamine for the treatment of depression, as described by a psychiatric researcher specializing in depression and anxiety disorders.
ChapterHow Ketamine Works as an Antidepressant
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
The pioneers of ketamine research had an incredible tool, but no conceptual framework to generate scientific insight.
1:11:59 - 1:16:12 (04:13)
Summary
The pioneers of ketamine research had an incredible tool, but no conceptual framework to generate scientific insight. The drug was shorter-acting and safer than its predecessor phencyclidine, but the field was 30 years behind and little was known about the binding site for fencycloidine.