Chapter
Potential Age-Related Health Benefits of Rapamycin Confirmed in Mice
32:47 - 42:42 (09:54)
Rapamycin and caloric restriction show promise in increasing longevity and reducing the decline in bodily functions and diseases as shown in mice, and are believed to have potential benefits for people as well. However, further research is required to confirm the same effect in human beings.
Clips
The idea of conducting a clinical trial in dogs to study the biology of aging has been around for about 10 years, and rapamycin is one intervention that has the potential to extend a dog's lifespan and healthspan.
32:47 - 36:39 (03:51)
Summary
The idea of conducting a clinical trial in dogs to study the biology of aging has been around for about 10 years, and rapamycin is one intervention that has the potential to extend a dog's lifespan and healthspan. While there are concerns regarding the side effects of rapamycin, research is being done to determine if it can be used safely.
ChapterPotential Age-Related Health Benefits of Rapamycin Confirmed in Mice
Episode#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"
PodcastThe Tim Ferriss Show
Rapamycin has been found to reverse or delay brain degeneration in mouse models of Alzheimer's disease and other neurodegenerative diseases, resulting in improvements in cognitive function.
36:39 - 37:37 (00:58)
Summary
Rapamycin has been found to reverse or delay brain degeneration in mouse models of Alzheimer's disease and other neurodegenerative diseases, resulting in improvements in cognitive function.
ChapterPotential Age-Related Health Benefits of Rapamycin Confirmed in Mice
Episode#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"
PodcastThe Tim Ferriss Show
Despite initial concerns, rapamycin has been shown to enhance muscle growth and functioning in aging animals due to its promotion of protein synthesis through the mTOR pathway.
37:37 - 40:09 (02:31)
Summary
Despite initial concerns, rapamycin has been shown to enhance muscle growth and functioning in aging animals due to its promotion of protein synthesis through the mTOR pathway.
ChapterPotential Age-Related Health Benefits of Rapamycin Confirmed in Mice
Episode#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"
PodcastThe Tim Ferriss Show
This podcast discusses the science behind caloric restriction and how it affects the aging process in mice and dogs.
40:09 - 41:28 (01:18)
Summary
This podcast discusses the science behind caloric restriction and how it affects the aging process in mice and dogs. While there is evidence of a positive effect on lifespan, it may not be as significant in humans.
ChapterPotential Age-Related Health Benefits of Rapamycin Confirmed in Mice
Episode#617: In Case You Missed It: July 2022 Recap of "The Tim Ferriss Show"
PodcastThe Tim Ferriss Show
While some interventions may proportionately extend healthspan, nothing has ever convincingly extended the end period of life, or the decrepit state, which is a hard question to resolve.
41:28 - 42:42 (01:14)
Summary
While some interventions may proportionately extend healthspan, nothing has ever convincingly extended the end period of life, or the decrepit state, which is a hard question to resolve. However, rapamycin and caloric restriction seem to push the declines in function and diseases back later into life, disproportionately extending the healthspan in mice compared to lifespan.