Chapter
Re-thinking the Biology of Depression
49:37 - 55:55 (06:18)
The traditional idea that depression is caused by a disorder of serotonin cells in the midbrain and brain stem may be flawed, leading researchers to consider the role of other brain regions responsible for regulating emotion, processing reward, making plans, and interpreting the world.
Clips
The idea that depression is caused by a disorder of the few serotonin cells in the brain is flawed.
49:37 - 52:23 (02:46)
Summary
The idea that depression is caused by a disorder of the few serotonin cells in the brain is flawed. Instead, depression may have a major part of its biology in the higher cognitive centers of the brain, such as the cerebral cortex and the limbic system, which are predominantly driven by different chemical messengers than serotonin and norepinephrine.
ChapterRe-thinking the Biology of Depression
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
The cerebral cortex and limbic system work in a dynamic tension between the main excitatory driver for brain activity, glutamate, and GABA, the main inhibitory transmitter of the cortex.
52:23 - 55:55 (03:32)
Summary
The cerebral cortex and limbic system work in a dynamic tension between the main excitatory driver for brain activity, glutamate, and GABA, the main inhibitory transmitter of the cortex. Ketamine is being studied to understand its role in synaptic signaling in disorders related to schizophrenia.