Chapter
The Ambiguity of Amyloid in Brain Changes
2:08:38 - 2:15:41 (07:03)
The focus of amyloid in anti-amyloid therapies and biomarkers for cognitive impairment is causing a crisis in the field as there is much ambiguity surrounding the responsibility of amyloid for brain changes. While autopsies show high levels of amyloids in healthy individuals, lower amyloid levels are still believed to be better with the use of serum amyloid biomarkers in high-risk patients.
Clips
The role of amyloid in Alzheimer's disease is not crystal clear since there are healthy people with lots of amyloid plaques in their brains.
2:08:38 - 2:11:23 (02:45)
Summary
The role of amyloid in Alzheimer's disease is not crystal clear since there are healthy people with lots of amyloid plaques in their brains. Some individuals with deterministic genes may get early onset of disease, making the diagnosis more apparent, but it is still uncertain how important amyloid is for the disease.
ChapterThe Ambiguity of Amyloid in Brain Changes
EpisodeDr. Peter Attia: Improve Vitality, Emotional & Physical Health & Lifespan
PodcastHuberman Lab
The field of anti-amyloid therapies and biomarkers for Alzheimer's disease is in crisis due to the over-reliance on these methods.
2:11:23 - 2:15:41 (04:18)
Summary
The field of anti-amyloid therapies and biomarkers for Alzheimer's disease is in crisis due to the over-reliance on these methods. While serum amyloid biomarkers are used in high-risk patients, only sleep and lower LDL cholesterol are unequivocally linked to brain health.