Chapter
The Future of NMDA Receptor Antagonists for Depression Treatment
3:29:48 - 3:40:27 (10:38)
The current generation of NMDA receptor antagonists, particularly NR2B antagonists and ketamine combination therapies, will be fully understood within the next five to ten years. Additionally, studies suggest other neurotrophic factors, as well as exercise, can also be helpful in treating depression.
Clips
The effects of neurotrophic factors like BDNF have been studied in relation to the antidepressant effects of ketamine and psychedelics, as well as SSRIs and other antidepressants.
3:29:48 - 3:32:26 (02:38)
Summary
The effects of neurotrophic factors like BDNF have been studied in relation to the antidepressant effects of ketamine and psychedelics, as well as SSRIs and other antidepressants. While raising BDNF levels can improve both synaptic efficacy and density, the exact role it plays in the increase of dendritic growth and synaptic density is still being researched.
ChapterThe Future of NMDA Receptor Antagonists for Depression Treatment
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Exercise promotes the expression of BDNF, a protein which has a crucial role in promoting neural plasticity and growth, leading to psychological improvements following exercise.
3:32:26 - 3:34:28 (02:01)
Summary
Exercise promotes the expression of BDNF, a protein which has a crucial role in promoting neural plasticity and growth, leading to psychological improvements following exercise. Ketone body beta hydroxybutyrate is also involved in promoting the expression of BDNF.
ChapterThe Future of NMDA Receptor Antagonists for Depression Treatment
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
The current generation of NMDA receptor antagonists such as NR2B antagonists, R-ketamine, and combination therapies with ketamine will settle out within the next five to ten years, while increasing exercise to reasonably high levels can be helpful for depression by raising BDNF and synergizing with antidepressant treatment.
3:34:28 - 3:40:27 (05:59)
Summary
The current generation of NMDA receptor antagonists such as NR2B antagonists, R-ketamine, and combination therapies with ketamine will settle out within the next five to ten years, while increasing exercise to reasonably high levels can be helpful for depression by raising BDNF and synergizing with antidepressant treatment.