Chapter
The Genetics of Obesity
1:04:00 - 1:15:38 (11:38)
The FTO genetic variant is associated with obesity and controls two genes, IRX3 and IRX5, which are sitting 1.2 million nucleotides away. A deep understanding of this circuitry is allowing for improvements in tissue-specific wiring and the development of therapeutics.
Clips
Rising from the basic building blocks of understanding the human genome, a group of scientists seeks to solve the circuitry involved in gene expressions, allowing for a deeper understanding of how every single nucleotide works throughout the body.
1:04:00 - 1:07:27 (03:27)
Summary
Rising from the basic building blocks of understanding the human genome, a group of scientists seeks to solve the circuitry involved in gene expressions, allowing for a deeper understanding of how every single nucleotide works throughout the body.
ChapterThe Genetics of Obesity
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The deep understanding of the basic circuitry is crucial to developing therapeutics for various disorders, and it allows scientists to improve the circuitry instead of treating it as a black box.
1:07:27 - 1:09:14 (01:46)
Summary
The deep understanding of the basic circuitry is crucial to developing therapeutics for various disorders, and it allows scientists to improve the circuitry instead of treating it as a black box.
ChapterThe Genetics of Obesity
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The FTO gene has the strongest genetic association with obesity, but variations in this gene may also impact other nearby genes like IRX3 and IRX5.
1:09:14 - 1:13:41 (04:27)
Summary
The FTO gene has the strongest genetic association with obesity, but variations in this gene may also impact other nearby genes like IRX3 and IRX5. This makes it difficult to determine the exact gene-disease relationship.
ChapterThe Genetics of Obesity
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
Understanding gene expression in specific tissues requires analyzing the circuitry, genetic variants' impact on gene expression, and identifying epigenomic enrichments outside of proteins corresponding to non-coding variants.
1:13:41 - 1:15:38 (01:57)
Summary
Understanding gene expression in specific tissues requires analyzing the circuitry, genetic variants' impact on gene expression, and identifying epigenomic enrichments outside of proteins corresponding to non-coding variants.