The vitamin D receptor plays a crucial role in longevity, as seen in animal studies where animals lacking the receptor had a shorter lifespan. Vitamin D supplements have also been shown to reverse epigenetic aging in humans with deficiencies.
The podcast discusses the importance of vitamin D conversion and its relationship to all-cause mortality. Additionally, it explains the different ways in which people can obtain vitamin D, such as getting enough sun exposure, being physically active, or taking supplements.
The risk of hypercalcemia due to high levels of vitamin D3 supplementation is extremely rare according to scientific literature. A dosage of at least 4,000 IUs is recommended to raise vitamin D levels from 20 to 40 nanograms per milliliter if there are no genetic changes affecting vitamin D metabolism.
Vitamin D receptor plays a crucial role in complexing with retinoid receptor, going into the nucleus of complex, and turning on/off genes. Studies suggest that exposing more skin to sun and maintaining sufficient levels of vitamin D can reverse epigenetic aging by three years.