A study in mice shows that dietary consumption of spermidine can increase lifespan and improve health outcomes. Spermidine has been shown to boost a specific type of autophagy, called mitophagy, which helps clear damage and recycle components for optimal cellular function.
A new clinical trial funded by a company developing Urolithin A supplements has shown signs of improvements in muscle function for older individuals, which supports the notion that it enhances mitophagy. The mechanism behind 17-alpha estradiol's lifespan extension properties is still unknown.
Research has shown that vascular disease is not a major cause of death in mice, unlike cancer which accounts for between 60-90% of deaths. Therefore, interventions that prevent vascular disease or heart disease would not have a significant impact on mouse lifespan if not for their impact on cancer and other age-related diseases.
This podcast discusses the use of Deprinil, NAD, and other anti-aging compounds, specifically their effects on rodent and dog lifespan as well as the growing trend of NAD intravenous pushes in the wellness industry.