Chapter
The Lifespan Extension Properties of Spermidine and Deprinil
56:27 - 1:03:26 (06:59)
This podcast episode discusses studies conducted on mice and dogs that demonstrated the lifespan extension effects of spermidine and Deprinil, and the potential benefits for age-related diseases.
Clips
A study in mice shows that dietary consumption of spermidine can increase lifespan and improve health outcomes.
56:27 - 59:08 (02:41)
Summary
A study in mice shows that dietary consumption of spermidine can increase lifespan and improve health outcomes. Spermidine has been shown to boost a specific type of autophagy, called mitophagy, which helps clear damage and recycle components for optimal cellular function.
ChapterThe Lifespan Extension Properties of Spermidine and Deprinil
Episode#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
PodcastThe Tim Ferriss Show
A new clinical trial funded by a company developing Urolithin A supplements has shown signs of improvements in muscle function for older individuals, which supports the notion that it enhances mitophagy.
59:08 - 1:00:11 (01:03)
Summary
A new clinical trial funded by a company developing Urolithin A supplements has shown signs of improvements in muscle function for older individuals, which supports the notion that it enhances mitophagy. The mechanism behind 17-alpha estradiol's lifespan extension properties is still unknown.
ChapterThe Lifespan Extension Properties of Spermidine and Deprinil
Episode#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
PodcastThe Tim Ferriss Show
Research has shown that vascular disease is not a major cause of death in mice, unlike cancer which accounts for between 60-90% of deaths.
1:00:11 - 1:01:17 (01:05)
Summary
Research has shown that vascular disease is not a major cause of death in mice, unlike cancer which accounts for between 60-90% of deaths. Therefore, interventions that prevent vascular disease or heart disease would not have a significant impact on mouse lifespan if not for their impact on cancer and other age-related diseases.
ChapterThe Lifespan Extension Properties of Spermidine and Deprinil
Episode#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
PodcastThe Tim Ferriss Show
This podcast discusses the use of Deprinil, NAD, and other anti-aging compounds, specifically their effects on rodent and dog lifespan as well as the growing trend of NAD intravenous pushes in the wellness industry.
1:01:17 - 1:03:26 (02:08)
Summary
This podcast discusses the use of Deprinil, NAD, and other anti-aging compounds, specifically their effects on rodent and dog lifespan as well as the growing trend of NAD intravenous pushes in the wellness industry.