Chapter
The Neuroscience Behind Bipolar Disorder and Lithium Treatment
1:12:30 - 1:24:36 (12:06)
A study shows that people with high risk of or full-blown bipolar disorder have deficits in connectivity between parietal brain regions and the limbic system. Lithium's positive effects on bipolar depression treatment may be due to its prevention of the loss of neural circuits for interoception and control over the limbic system.
Clips
Researchers have discovered hyperactivity in certain neural circuits in people with bipolar disorder that over time actually causes those circuits to diminish, in addition to the circuits for interoception that wane and disappear.
1:12:30 - 1:17:27 (04:56)
Summary
Researchers have discovered hyperactivity in certain neural circuits in people with bipolar disorder that over time actually causes those circuits to diminish, in addition to the circuits for interoception that wane and disappear. This article highlights what is known about the neural circuits that lead to the manic states in bipolar disorder.
ChapterThe Neuroscience Behind Bipolar Disorder and Lithium Treatment
EpisodeThe Science & Treatment of Bipolar Disorder
PodcastHuberman Lab
A recent study analyzing neural circuits of individuals with bipolar disorder has shown deficits in connectivity between the parietal brain regions and the limbic system, leading to researchers hypothesizing that the limbic system may be operating at higher levels in these individuals.
1:17:27 - 1:21:42 (04:14)
Summary
A recent study analyzing neural circuits of individuals with bipolar disorder has shown deficits in connectivity between the parietal brain regions and the limbic system, leading to researchers hypothesizing that the limbic system may be operating at higher levels in these individuals.
ChapterThe Neuroscience Behind Bipolar Disorder and Lithium Treatment
EpisodeThe Science & Treatment of Bipolar Disorder
PodcastHuberman Lab
By examining the effects of lithium at a reductionist level, researchers can gain important insight into how the drug and other treatments for bipolar disorder can benefit patients.
1:21:42 - 1:24:36 (02:54)
Summary
By examining the effects of lithium at a reductionist level, researchers can gain important insight into how the drug and other treatments for bipolar disorder can benefit patients. Lithium appears to prevent the loss of certain neural circuits, using a form of neuroplasticity called homeostatic plasticity to regulate overactive circuits.