Chapter
The Science of Serotonin and Depression
42:56 - 49:37 (06:40)
The simple-minded idea that low serotonin leads to depression and normal serotonin leads to a healthy life could not be true. However, neuroadaptations associated with serotonin synapses underlay the antidepressant effects of drugs like Prozac.
Clips
The role of serotonin and norepinephrine in depression and antidepressant treatment is a topic that has been studied for years through neuroendocrine responses and behavior.
42:56 - 45:10 (02:13)
Summary
The role of serotonin and norepinephrine in depression and antidepressant treatment is a topic that has been studied for years through neuroendocrine responses and behavior. This podcast discusses inferring what is happening inside by analyzing what is happening outside in certain brain connections after a drug is administered.
ChapterThe Science of Serotonin and Depression
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
Researchers found that the tryptophan depletion technique supports the idea that neuroadaptations associated with serotonin synapses underlie the antidepressant effects of SSRIs like Prozac.
45:10 - 47:17 (02:07)
Summary
Researchers found that the tryptophan depletion technique supports the idea that neuroadaptations associated with serotonin synapses underlie the antidepressant effects of SSRIs like Prozac.
ChapterThe Science of Serotonin and Depression
Episode#625: Dr. John Krystal — All Things Ketamine, The Most Comprehensive Podcast Episode Ever
PodcastThe Tim Ferriss Show
It is widely assumed that depression is caused by a chemical imbalance of low serotonin levels, but the reality is much more complex.
47:17 - 49:37 (02:19)
Summary
It is widely assumed that depression is caused by a chemical imbalance of low serotonin levels, but the reality is much more complex. While there is evidence to suggest that changes in serotonin regulation can be intrinsic to the biology of depression, the idea that depression is a pure deficit in serotonin is too simplistic.