Chapter
Unbiased View of Tissue that Underlie Disorders
52:16 - 1:04:00 (11:43)
By looking at the enrichment of genetic variants in enhancers found in T cells and B cells, researchers found Alzheimer's disease was strongly connected to microglia cells, which could lead to clinical trials in humans to reverse these processes.
Clips
Enhancers, gene regulatory elements active in T cells, B cells and hematopoietic stem cells, contain genetic variants associated with immune traits like allergies and type one diabetes.
52:16 - 55:20 (03:03)
Summary
Enhancers, gene regulatory elements active in T cells, B cells and hematopoietic stem cells, contain genetic variants associated with immune traits like allergies and type one diabetes. The matrix showing which genetic traits are enriched in which tissues in the body revealed enhancers in the left external of the heart containing genetic variants associated with blood pressure, while inflammatory bowel disease revealed traits associated with both immune and digestive systems.
ChapterUnbiased View of Tissue that Underlie Disorders
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
Microglia are resident immune cells in your brain, similar to tissue-specific monocytes that are basically sitting in your brain.
55:20 - 56:05 (00:44)
Summary
Microglia are resident immune cells in your brain, similar to tissue-specific monocytes that are basically sitting in your brain. The M1 versus M2 macrophage ratio plays a crucial role in obesity in the macrophages that are present in every tissue, including the brain's microglia.
ChapterUnbiased View of Tissue that Underlie Disorders
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
Understanding the tissue of action and pathway of action in mice can lead to the development of safe and effective drugs for humans.
56:05 - 1:01:06 (05:01)
Summary
Understanding the tissue of action and pathway of action in mice can lead to the development of safe and effective drugs for humans. By screening molecules directly for the pathway in a specific cell type, a high throughput multiplexed system can be developed for drug testing.
ChapterUnbiased View of Tissue that Underlie Disorders
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
Coordinating efforts to understand the circuitry of the human genome is crucial in developing solutions for various diseases, including schizophrenia and Alzheimer's.
1:01:06 - 1:04:00 (02:53)
Summary
Coordinating efforts to understand the circuitry of the human genome is crucial in developing solutions for various diseases, including schizophrenia and Alzheimer's. The Epigenomics roadmap that comprises 833 different tissues is an important resource in this endeavor.