Chapter
Understanding Gene Regulation through Genetic Variants
1:25:00 - 1:33:25 (08:25)
Exploring the connection between genetic variants, epigenomes, and the expression of nearby genes to understand gene regulation. By looking at different human variations, scientists can identify gene regulatory words, which can then help to understand dysregulatory events.
Clips
The process of identifying the causal variant linked to obesity is discussed, which includes figuring out the disrupted gene regulatory word.
1:25:00 - 1:27:09 (02:08)
Summary
The process of identifying the causal variant linked to obesity is discussed, which includes figuring out the disrupted gene regulatory word. The genetic variants associated with obesity were found to be enriched in mesenchymal stem cell enhancers.
ChapterUnderstanding Gene Regulation through Genetic Variants
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The process of how chromosomes fold and pack tightly within the nucleolus is still not completely understood.
1:27:09 - 1:31:24 (04:15)
Summary
The process of how chromosomes fold and pack tightly within the nucleolus is still not completely understood. Researchers use various techniques, such as ligation events and perturbation experiments, to study the folding of chromosomes and the impact of genetic variants on gene expression.
ChapterUnderstanding Gene Regulation through Genetic Variants
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The link between genetic variants and the expression of nearby genes is key to identifying genetic links to disease.
1:31:24 - 1:33:25 (02:01)
Summary
The link between genetic variants and the expression of nearby genes is key to identifying genetic links to disease. By studying the relationship between different genetic variants and the expression of genes nearby, researchers can begin to understand the genetic links to different diseases.