Chapter
Understanding Protein Evolution through Sequence Patterns
53:17 - 1:00:02 (06:45)
Researchers analyze protein sequences to understand their evolutionary patterns and have discovered an additional gene encoded within the ORF3A gene. By scanning the DNA's sequence patterns, researchers can identify how a gene has evolved.
Clips
The evolution of protein-coding genes depends on the level of evolutionary selection, where mutations that do not affect the function of the protein are tolerated.
53:17 - 56:49 (03:32)
Summary
The evolution of protein-coding genes depends on the level of evolutionary selection, where mutations that do not affect the function of the protein are tolerated. Changing a codon position in a triplet encoding for an amino acid will not significantly affect the function of the protein.
ChapterUnderstanding Protein Evolution through Sequence Patterns
Episode#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics
PodcastLex Fridman Podcast
The evolutionary signatures in the ORF3A gene of the coronavirus genome suggests the presence of a tiny additional gene encoded within.
56:49 - 1:00:02 (03:13)
Summary
The evolutionary signatures in the ORF3A gene of the coronavirus genome suggests the presence of a tiny additional gene encoded within. Applying this concept to the SARS-CoV-2 genome could help identify which genes are evolving like proteins and which ones are not.