Chapter
Understanding the Complexities of Genetics and Brain Function
16:30 - 29:11 (12:41)
This podcast episode discusses the various levels of genetic components that relate to molecular and cellular variations that affect the different functions of brain cells. With thousands of individuals each with a unique genetic variation and phenotype, researchers are able to analyze the correlations between genetics and brain function.
Clips
With the advent of modern genetics, researchers are able to examine the DNA and phenotypes of thousands of unrelated individuals to trace inheritance patterns and identify the specific genes responsible for certain diseases, potentially leading to improved treatments for a wide range of conditions.
16:30 - 19:42 (03:12)
Summary
With the advent of modern genetics, researchers are able to examine the DNA and phenotypes of thousands of unrelated individuals to trace inheritance patterns and identify the specific genes responsible for certain diseases, potentially leading to improved treatments for a wide range of conditions.
ChapterUnderstanding the Complexities of Genetics and Brain Function
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
Researchers aim to systematically connect genetic variation with molecular variation at different levels, including expression, gene regulation, and single-cell profiling in order to understand the impact of these perturbations on cellular and organ levels and relate them to various traits and diseases.
19:42 - 21:35 (01:52)
Summary
Researchers aim to systematically connect genetic variation with molecular variation at different levels, including expression, gene regulation, and single-cell profiling in order to understand the impact of these perturbations on cellular and organ levels and relate them to various traits and diseases.
ChapterUnderstanding the Complexities of Genetics and Brain Function
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
The different types of neurons and glial cells have different functions in cognition, environment interaction, brain maintenance, energetic needs, blood and oxygen supply, and debris clearing.
21:35 - 27:13 (05:37)
Summary
The different types of neurons and glial cells have different functions in cognition, environment interaction, brain maintenance, energetic needs, blood and oxygen supply, and debris clearing. Single-cell profiling can help experimentally deconvolute the complexity of the brain on different levels by breaking up the long path into smaller levels and performing genetic analysis and computational analysis.
ChapterUnderstanding the Complexities of Genetics and Brain Function
Episode#133 – Manolis Kellis: Biology of Disease
PodcastLex Fridman Podcast
This episode discusses how measuring genetic, epigenomic, transcriptomic, and cellular properties can provide insights into disease and related endophenotypes like brain activity.
27:13 - 29:11 (01:58)
Summary
This episode discusses how measuring genetic, epigenomic, transcriptomic, and cellular properties can provide insights into disease and related endophenotypes like brain activity.