Chapter
Understanding the Statistical Analysis of Clinical Trials
1:59:00 - 2:08:51 (09:51)
The statistical analysis of clinical trials involves calculating the effect size of different treatments and determining the sample size needed for the study. The placebo subtracted effect size is used to measure the effect of the treatment, while sample size re-estimation is done in phase three trials to account for any variations in the results.
Clips
Interim analysis is important in clinical trials as it helps in sample-size re-estimation, meaning that it helps to determine how many people are needed to complete the trial.
1:59:00 - 2:03:50 (04:50)
Summary
Interim analysis is important in clinical trials as it helps in sample-size re-estimation, meaning that it helps to determine how many people are needed to complete the trial. This is done by analyzing the data collected from the trial to help determine the effect size and the statistical significance of the results.
ChapterUnderstanding the Statistical Analysis of Clinical Trials
Episode#202 – Rick Doblin: Psychedelics
PodcastLex Fridman Podcast
The odds of a drug being approved after two phase three studies are 0.025, but if a robust result is achieved, it may be possible to be approved based on just one study.
2:03:51 - 2:06:41 (02:50)
Summary
The odds of a drug being approved after two phase three studies are 0.025, but if a robust result is achieved, it may be possible to be approved based on just one study. However, getting statistical significance in a study can be challenging.
ChapterUnderstanding the Statistical Analysis of Clinical Trials
Episode#202 – Rick Doblin: Psychedelics
PodcastLex Fridman Podcast
This podcast discusses the placebo subtracted effect size and how it is used to measure the effect of MDMA in therapy.
2:06:41 - 2:08:51 (02:10)
Summary
This podcast discusses the placebo subtracted effect size and how it is used to measure the effect of MDMA in therapy. An effect size of one means that results are one standard deviation away from the norm, while two standard deviations away is considered an enormous effect size.