In a study on the effects of metformin supplementation on the lifespan of Fisher 344 rats, no significant lifespan extension was observed. While it's important to standardize dosage, it may be more effective to mix metformin into the animals' food rather than injecting them with it directly.
The Canine Longevity Project is a study aiming to identify genetic factors associated with healthy aging in dogs. Pet owners interested in participating can speak to their veterinarian about the project and potentially prescribe a medication off-label under veterinary supervision.
The speaker shares that they have been working and talking with the FDA to develop a drug for animal health that requires FDA approval since the beginning, adding that a weight loss drug was unsuccessful in the animal health industry in the past.
Researchers have identified six or seven small molecules that could potentially extend the health span of dogs, including metformin and others that have shown evidence of beneficial effects on metabolic health and overall health.
Discover the efforts in mitigating heart failure in large dogs, with the study of other markers of health span also showing improvements in canine companions. However, limited funding and high costs make the research challenging.
The use of anabolic androgenic steroids (AAS) can have negative effects on testosterone production, libido and adolescent development, as evidenced by case studies, although it's important not to overinterpret these anecdotal reports.