Episode
#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
1:18:36
Published: Sun Sep 25 2016
Description
Dr. Dominic "Dom" D'Agostino (@DominicDAgosti2) is one of my most popular guests, and I'm happy to have him rejoin the show for the third time. (You can listen to Dom's first appearance here, and his second appearance here). Dom is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC) -- which is mentioned in the current issue of Outside Magazine (on which there's a clown who looks a lot like me). Much of Dom's work is related to metabolic therapies and nutritional strategies for peak performance and resilience in extreme environments. Dom's research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), and other private organizations and foundations. In this episode, Dom focuses on disease prevention, cancer, and more mastery of the ketogenic diet. Please enjoy this tutorial and masterclass with Dominic D'Agostino. Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by Vimeo Business. Vimeo Business has all of the prior benefits of Vimeo Pro, including VIP support. Whether you make videos for a living, run your own company, or simply want to amp up your video marketing, Vimeo Business is here to help. It has more than 280 million creators and viewers worldwide and makes it easier to share your videos with a global audience and connect with professional video makers to bring your stories to life. Vimeo Business allows you to upload up to five terabytes and store your videos in one secure place, add up to 10 team members to your account for easy collaboration, and gather feedback with seamless review tools. You can even add clickable calls to action and capture email addresses directly in the player, which can help you generate leads and drive conversion for whatever you're trying to optimize -- such as a newsletter or a sales page. Check out vimeo.com/tim10 to save 10 percent on Vimeo Business. This podcast is also brought to you by Wealthfront. Wealthfront is a massively disruptive (in a good way) set-it-and-forget-it investing service led by technologists from places like Apple. It has exploded in popularity in the last two years and now has more than $2.5B under management. Why? Because you can get services previously limited to the ultra-wealthy and only pay pennies on the dollar for them, and it's all through smarter software instead of retail locations and bloated sales teams. Check out wealthfront.com/tim, take their risk assessment quiz, which only takes 2-5 minutes, and they'll show you -- for free -- exactly the portfolio they'd put you in. If you want to just take their advice and do it yourself, you can. Well worth a few minutes to explore: wealthfront.com/tim.***If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Interested in sponsoring the podcast? Visit tim.blog/sponsor and fill out the form.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Chapters
The episode includes an ad for Tim Ferriss' email newsletter, Five Bullet Friday, which features short and sweet bullet points of the coolest things he’s found that week.
00:00 - 01:21 (01:21)
Summary
The episode includes an ad for Tim Ferriss' email newsletter, Five Bullet Friday, which features short and sweet bullet points of the coolest things he’s found that week.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
In this repeat episode of the Tim Ferriss Show, Dr. Dominic D'Agostino discusses his focus on disease prevention, cancer, and mastery of the ketogenic diet.
01:21 - 06:54 (05:32)
Summary
In this repeat episode of the Tim Ferriss Show, Dr. Dominic D'Agostino discusses his focus on disease prevention, cancer, and mastery of the ketogenic diet. He addresses whether the ketogenic diet beats chemotherapy for all cancers, and explains that it should not be the preferred therapy for some cancers but can be used as an adjuvant or support for various cancer therapies.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
The ketogenic diet when properly administered can enhance the efficacy of standard of care for aggressive metastatic cancer and brain tumors, including glioblastoma.
06:54 - 11:37 (04:43)
Summary
The ketogenic diet when properly administered can enhance the efficacy of standard of care for aggressive metastatic cancer and brain tumors, including glioblastoma. Studies show that nutritional ketosis enhances the tumor killing effect of radiation and reduces glycolytic flux through the tumors while impacting their antioxidant status.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
The ketogenic diet has shown promise as an adjuvant to metabolic therapy in managing cancer due to its ability to target tumors that have a Warburg phenotype, which includes about 80-90% of cancers.
11:37 - 16:11 (04:34)
Summary
The ketogenic diet has shown promise as an adjuvant to metabolic therapy in managing cancer due to its ability to target tumors that have a Warburg phenotype, which includes about 80-90% of cancers. Achieving a glucose ketone index of one or two is optimal for therapeutic purposes, and can be jump-started through exogenous ketones or exercise.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
In this podcast, Ben Greenfield provides tips for preserving muscle mass during prolonged fasts.
16:11 - 21:04 (04:53)
Summary
In this podcast, Ben Greenfield provides tips for preserving muscle mass during prolonged fasts. He recommends consuming branched chain amino acids (BCAAs) before and during the fast, as well as doing short bouts of low-intensity exercise to activate the sympathetic nervous system and mobilize free fatty acids for fuel.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
The ketogenic diet is a low-carb, high-fat diet that has been touted for its many health benefits, including cancer prevention and treatment.
21:04 - 27:04 (05:59)
Summary
The ketogenic diet is a low-carb, high-fat diet that has been touted for its many health benefits, including cancer prevention and treatment. In this podcast, Dr. Colin Champ discusses the science behind the ketogenic diet and its potential benefits in managing cancer, as well as the ongoing clinical trials.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Nutritional ketosis can enhance the safety and efficacy of hyperbaric oxygen therapy, preventing potential CNS oxygen toxicity seizures, and crippling the antioxidant defenses of highly glycolytic tumor cells while hyperbaric oxygen therapy saturates tumors with oxygen and stimulates oxidative stress.
27:04 - 33:05 (06:01)
Summary
Nutritional ketosis can enhance the safety and efficacy of hyperbaric oxygen therapy, preventing potential CNS oxygen toxicity seizures, and crippling the antioxidant defenses of highly glycolytic tumor cells while hyperbaric oxygen therapy saturates tumors with oxygen and stimulates oxidative stress.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Nutritional ketosis and intermittent fasting can have favorable metabolic and signaling effects for those with Apolipoprotein E4 (APO E4) gene.
33:05 - 42:32 (09:26)
Summary
Nutritional ketosis and intermittent fasting can have favorable metabolic and signaling effects for those with Apolipoprotein E4 (APO E4) gene. A study by Sam Henderson showed that APO E4 positive patients did not respond as well to medium chain triglyceride (MCT) oil based supplements, so actual carbohydrate restriction associated with nutritional ketosis may be more beneficial.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Dr. Rhonda Patrick discusses strategies for a controlled cheat meal and the metabolic advantages of ketogenic diet.
42:32 - 52:27 (09:55)
Summary
Dr. Rhonda Patrick discusses strategies for a controlled cheat meal and the metabolic advantages of ketogenic diet. She suggests adding fats and cap off the total calorie count of a cheat meal to avoid excess carb intake that could lead to a hypoglycemic effect. On the topic of ketogenic diet, she highlights how sustained nutritional ketosis enhances metabolic efficiency and suppresses appetite to naturally consume fewer calories.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Metformin is a widely used drug for diabetes management that has shown certain benefits, but its long-term effects are uncertain.
52:27 - 56:24 (03:57)
Summary
Metformin is a widely used drug for diabetes management that has shown certain benefits, but its long-term effects are uncertain. The drug is known to cause photosensitivity and GI discomfort and may reduce the utilization of B12.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Dr. Peter Attia discusses the combination of intense weight training and a ketogenic diet for optimal health and longevity.
56:24 - 1:00:20 (03:56)
Summary
Dr. Peter Attia discusses the combination of intense weight training and a ketogenic diet for optimal health and longevity. While a ketogenic diet can be used for glycolytic training, it's important to train and follow the diet consistently over a long period to get the benefits.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
The discipline and structure that comes from weight training helped Gerard E Dawson become more motivated and successful in his academic pursuits, with weight training providing a strong foundation for mental and physical resilience.
1:00:20 - 1:06:41 (06:20)
Summary
The discipline and structure that comes from weight training helped Gerard E Dawson become more motivated and successful in his academic pursuits, with weight training providing a strong foundation for mental and physical resilience.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Dr. Dominic D'Agostino discusses the safety of various forms of exogenous ketones in the market, specifically highlighting the potential dangers of the DL beta hydroxybutyrate salts.
1:06:41 - 1:16:19 (09:37)
Summary
Dr. Dominic D'Agostino discusses the safety of various forms of exogenous ketones in the market, specifically highlighting the potential dangers of the DL beta hydroxybutyrate salts. He delves into the research on the topic as well as the benefits of using these products.
Episode#188: Dom D'Agostino on Disease Prevention, Cancer, and Living Longer
PodcastThe Tim Ferriss Show
Tim Ferriss discusses the option of signing up for his short email, Five Bullet Friday, which provides cool findings and musings.
1:16:19 - 1:18:35 (02:16)
Summary
Tim Ferriss discusses the option of signing up for his short email, Five Bullet Friday, which provides cool findings and musings. He also talks about his product, ketone salts, and the feedback he has received on their use.