The lethal dose of LSD (LD50) has never been determined; however, it is estimated to be about 70,000 times the minimum dose, and there have been cases of heart attacks and strokes associated with LSD use but it's unclear if the drug was the direct cause.
This episode delves into the story of how LSD was discovered by accident and the impact it had on society.
The myth of acid flashbacks is rooted in anecdotal evidence and stories from the 60s and 70s, but there is no concrete evidence to support its existence. The minimum dose of LSD is a quarter microgram, much smaller than a typical acid hit today.
James Fadiman explains that microdosing is a sub perceptual amount of psychedelic taken on a frequent basis, which is believed to provide several benefits without the full psychedelic experience. However, studies have shown that microdosing can cause anxiety in some people.
Scientists conducted unethical experiments with an LSD-like compound by air dosing people at random while driving around cities in poorer and multicultural areas. The air dosing did not work well.
The hosts discuss the origins of LSD and describe drug's packaging from the 1960s. They note that doses were much lower in the past and speculate on contemporary venues for taking the drug.