Episode
Dr. Karl Deisseroth: Understanding & Healing the Mind
2:03:00
Published: Mon Jun 28 2021
Description
Dr. Karl Deisseroth, MD, PhD, is a Clinical Psychiatrist and scientist who directs a bioengineering research laboratory at Stanford University School of Medicine. His work aims to understand and develop treatments for disorders of the mind such as depression, attention deficit disorders (ADHD & ADD), autism, schizophrenia, anxiety, eating disorders, borderline personality and obsessive-compulsive disorder. We discuss his experience treating his patients and his laboratory’s mission to find and develop cures for mental disease and tools for probing how the brain works. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:03:47) Sponsors: AG1, LMNT, Thesis, Momentous (00:07:41) Using Language to Understand the Mind (00:12:19) Blood Tests For Mental Disease (00:13:38) The Largest Challenges Facing Treatment of Mental Health (00:20:21) Predicting Depression & Suicide (00:22:47) Drugs That Work for Brain Illness (00:27:01) What Would A Cure For the Broken Mind Look Like? (00:32:23) Channelopsins: Tools For Understanding & Treating the Mind (00:39:10) Curing Blindness with Channelopsins (00:41:58) Why Karl Became a Scientist (00:47:10) Vagus Nerve In Depression (00:54:12) Challenges To Overcome for Treating Mental Illness with Channelopsins (00:58:34) Using the Dialogue with Patients to Guide Treatment (01:00:52) How Our Eyes Reveal Our Mental Health (01:06:04) Controlling Structures Deep In the Brain (01:08:23) The Most Effective Drugs Often Have the Most Side Effects (01:09:50) Do Psychiatrists Take the Drugs They Prescribe (01:14:15) Moving From Experimental Tools To Novel Treatments (01:16:00) Brain-Machine Interfaces & Neuralink (01:19:30) ADHD & Dr. Deissroth’s Approach To Focusing His Mind (01:26:36) How Dr. Deisseroth Balances A Career In Medicine, Science & Family (01:35:41) New Ways of Exploring Brains: CLARITY (01:38:49) What Is Special About the Human Brain? (01:46:03) Psychedelics (01:54:12) MDMA (01:57:15) Dr. Deisseroth’s New Book “Projections: A Story of Emotions” (01:59:42) Connecting with Dr. Deisseroth on Twitter Title Card Photo Credit: Mike Blabac Disclaimer
Chapters
Dr. Carl Diceroff talks about his clinical practice and how he delves into the understanding of the brain by interacting with patients dealing with various nervous system disorders, while also sharing insights on the discovery of channelopsins and other technologies that may transform the fields of psychiatry, mental health, and health in general.
00:00 - 03:26 (03:26)
Summary
Dr. Carl Diceroff talks about his clinical practice and how he delves into the understanding of the brain by interacting with patients dealing with various nervous system disorders, while also sharing insights on the discovery of channelopsins and other technologies that may transform the fields of psychiatry, mental health, and health in general.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The podcast speaker discusses the relevance of hydration, electrolytes, and single-ingredient supplements for nerve cell function and optimizing your supplementation protocol, along with acknowledging the sponsors of the podcast.
03:27 - 08:54 (05:27)
Summary
The podcast speaker discusses the relevance of hydration, electrolytes, and single-ingredient supplements for nerve cell function and optimizing your supplementation protocol, along with acknowledging the sponsors of the podcast.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The psychiatrist speaks on the challenges of understanding patients' internal emotions, particularly in the context of anxiety and depression.
08:55 - 19:00 (10:05)
Summary
The psychiatrist speaks on the challenges of understanding patients' internal emotions, particularly in the context of anxiety and depression. They discuss the role of anticipation and hope in psychiatry and how it can be utilized to improve patient care.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The use of devices that detect changes in a person's body, such as sleep patterns, could help in predicting depressive episodes and reporting them to clinicians as an aid in the diagnosis of mental disorders.
19:00 - 22:52 (03:52)
Summary
The use of devices that detect changes in a person's body, such as sleep patterns, could help in predicting depressive episodes and reporting them to clinicians as an aid in the diagnosis of mental disorders.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Despite the mystery surrounding psychiatry, both medication and talk therapy have been shown to be effective in treating patients who suffer from symptoms of depression, and the treatments can have a quick and powerful effect for motivated and insightful patients.
22:52 - 30:47 (07:55)
Summary
Despite the mystery surrounding psychiatry, both medication and talk therapy have been shown to be effective in treating patients who suffer from symptoms of depression, and the treatments can have a quick and powerful effect for motivated and insightful patients.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Neuroscientists are using genetic tricks and light to better understand the complexity of merging data in the brain.
30:47 - 36:54 (06:06)
Summary
Neuroscientists are using genetic tricks and light to better understand the complexity of merging data in the brain. By inserting specific genes into the neurons of mammals and turning them on with light, researchers are able to study and manipulate specific cells involved in processing complex information.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Optogenetics has shown promising results in understanding the circuitry of retinal neurons and providing specific, principled treatments for patients with retinal degeneration.
36:54 - 42:20 (05:25)
Summary
Optogenetics has shown promising results in understanding the circuitry of retinal neurons and providing specific, principled treatments for patients with retinal degeneration. Recent success in putting channel redopsins into the eyes of human beings has even allowed a previously blind patient to see again.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
In this podcast, the potential of modifying the vagus nerve to treat severe depression is discussed.
42:20 - 50:49 (08:29)
Summary
In this podcast, the potential of modifying the vagus nerve to treat severe depression is discussed. The vagus nerve extends out of the skull and innervates several organs in the body, collecting and sending signals to the brain.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The field of medicine is focused on identifying pathways in the body that can be manipulated for symptom relief.
50:49 - 54:50 (04:01)
Summary
The field of medicine is focused on identifying pathways in the body that can be manipulated for symptom relief. Treatments may have originally been developed for one purpose, but end up being used for a completely different ailment.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
A bioengineer has developed a small blue light emitting device, similar to a clump of cells, which can stimulate the nodos ganglion in order to treat a variety of medical issues.
54:50 - 59:16 (04:26)
Summary
A bioengineer has developed a small blue light emitting device, similar to a clump of cells, which can stimulate the nodos ganglion in order to treat a variety of medical issues. Challenges still remain, including designing goggles that provide enough light, and tuning the light to respond to individual patient needs.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Eye contact is crucial in understanding non-verbal cues, but it's important to consider other aspects such as body language and verbal content.
59:16 - 1:08:51 (09:35)
Summary
Eye contact is crucial in understanding non-verbal cues, but it's important to consider other aspects such as body language and verbal content. Additionally, varying degrees of eye lubrication can influence frequency of blinking and should not be used to determine honesty.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Knowing the effects of medications, such as sleep disruption or libido disruption, can help physicians make better recommendations for their patients.
1:08:51 - 1:14:57 (06:06)
Summary
Knowing the effects of medications, such as sleep disruption or libido disruption, can help physicians make better recommendations for their patients. Weekly or periodic blood cell check-ins may also be necessary to monitor potential side effects.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Researchers are exploring the potential of developing pill-based treatments for neurological and psychiatric disorders by targeting specific sets of cells revealed through their work on channel opsins in the brain.
1:14:57 - 1:21:38 (06:41)
Summary
Researchers are exploring the potential of developing pill-based treatments for neurological and psychiatric disorders by targeting specific sets of cells revealed through their work on channel opsins in the brain.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The speaker questions whether the excessive use of phones and technology should be classified as ADHD or rather OCD.
1:21:38 - 1:27:31 (05:53)
Summary
The speaker questions whether the excessive use of phones and technology should be classified as ADHD or rather OCD. He emphasizes that any psychiatric diagnosis must disrupt a person's occupational or social wellbeing.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The speaker shares his writing process and the importance of getting single words and sentences right, using focus mode on his Macbook and dedicating midnight to 2 a.m. as his writing time.
1:27:32 - 1:34:21 (06:49)
Summary
The speaker shares his writing process and the importance of getting single words and sentences right, using focus mode on his Macbook and dedicating midnight to 2 a.m. as his writing time.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
Scientists have developed a gel that can be built inside brain tissue to link molecules together, allowing them to understand more about the microstructure of the brain and its cells' responses.
1:34:21 - 1:46:23 (12:02)
Summary
Scientists have developed a gel that can be built inside brain tissue to link molecules together, allowing them to understand more about the microstructure of the brain and its cells' responses. The breakthrough could give researchers greater understanding of the brain's natural processes and abilities.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
This podcast delves into the effects of compounds like LSD and psilocybin on brain functioning, particularly how they increase the willingness of our brain to accept unlikely ways of constructing the world but also can lead to induced psychiatric illness.
1:46:23 - 1:52:03 (05:39)
Summary
This podcast delves into the effects of compounds like LSD and psilocybin on brain functioning, particularly how they increase the willingness of our brain to accept unlikely ways of constructing the world but also can lead to induced psychiatric illness.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
In this episode, Dr. Andrew Huberman and Dr. Mark Plotkin discuss the future of psychiatry and brain science, including the use of non-hallucinatory variations of compounds like MDMA and the importance of creating stable and learned models to replace poor models that lead to psychiatric disorders like schizophrenia.
1:52:03 - 2:00:54 (08:50)
Summary
In this episode, Dr. Andrew Huberman and Dr. Mark Plotkin discuss the future of psychiatry and brain science, including the use of non-hallucinatory variations of compounds like MDMA and the importance of creating stable and learned models to replace poor models that lead to psychiatric disorders like schizophrenia.
EpisodeDr. Karl Deisseroth: Understanding & Healing the Mind
PodcastHuberman Lab
The partnership with Momentus Supplements is promoted, highlighting their high-quality single ingredient formulations as well as international shipping.
2:00:54 - 2:02:52 (01:58)
Summary
The partnership with Momentus Supplements is promoted, highlighting their high-quality single ingredient formulations as well as international shipping. A website and the first episode of the Huberman Lab podcast are also suggested for further information.