Episode
#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
1:49:34
Published: Mon Jun 07 2021
Description
David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors: - Onnit: https://lexfridman.com/onnit to get up to 10% off - Clear: https://clearme.com/lexpod and use code LexPod to get 2 months free - National Instruments (NI): https://www.ni.com/perspectives - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - Linode: https://linode.com/lex to get $100 free credit EPISODE LINKS: David's Twitter: https://twitter.com/davidasinclair David's Website: https://lifespanbook.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:34) - Staying young at heart (13:31) - Bringing people back to life (19:05) - Wearables and tracking health data (28:18) - How to solve aging (38:23) - Why do we age? (43:50) - Genetic reset switch that reverses aging (46:20) - AI in biology (48:52) - Health data (56:58) - Fasting (1:04:29) - Diet (1:12:41) - Exercise (1:18:01) - Sleep (1:26:29) - Data (1:32:00) - Extending lifespan (1:34:42) - Immortality (1:40:28) - Denial of death (1:43:45) - Meaning of life without death
Chapters
In this podcast episode, the speaker discusses how he views aging as an engineering problem that needs to be solved, and talks about his vision of a world where people can live much longer and healthier lives.
00:00 - 02:47 (02:47)
Summary
In this podcast episode, the speaker discusses how he views aging as an engineering problem that needs to be solved, and talks about his vision of a world where people can live much longer and healthier lives.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
Driver sensing technology not only accelerates the journey towards autonomous vehicles, but can also enrich the experience at any level.
02:47 - 10:24 (07:36)
Summary
Driver sensing technology not only accelerates the journey towards autonomous vehicles, but can also enrich the experience at any level. A HAL 9000 style system could enhance the collaboration between the vehicle and the humans, creating a better experience for both.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The guest and host discuss the idea of using artificial intelligence to bring back loved ones from the dead, and how the concept ties into the idea of staying young and curious forever.
10:24 - 17:01 (06:37)
Summary
The guest and host discuss the idea of using artificial intelligence to bring back loved ones from the dead, and how the concept ties into the idea of staying young and curious forever.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
With AI-assisted personalized health analysis, you can upload your own data at a minimal cost and get algorithms to guide your trajectory in life towards an extended and more fulfilling one.
17:01 - 28:38 (11:36)
Summary
With AI-assisted personalized health analysis, you can upload your own data at a minimal cost and get algorithms to guide your trajectory in life towards an extended and more fulfilling one. This eliminates the need for humans to manually do the work and connects scientific papers to individual data for better analysis.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The loss of information in the body is a root cause of aging.
28:38 - 34:47 (06:09)
Summary
The loss of information in the body is a root cause of aging. Exploring mechanisms that preserve information in cells, such as the silent information regulator, may lead to developing technology to improve the degradation of information and aging.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The process of cell differentiation determines the identity of a cell and how it will function.
34:47 - 39:49 (05:01)
Summary
The process of cell differentiation determines the identity of a cell and how it will function. Once a cell is differentiated, it becomes hard to change its identity or function because of the loss of information over time.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
Evidence suggests that creating DNA breaks can accelerate aging in animals and the recognition of such breaks by proteins alarms the cell to prevent cancer or cell death.
39:49 - 44:24 (04:34)
Summary
Evidence suggests that creating DNA breaks can accelerate aging in animals and the recognition of such breaks by proteins alarms the cell to prevent cancer or cell death.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
This podcast discusses the challenges of collecting and sharing health data at a large scale to better understand how to detect pathogens and characteristics of the human body.
44:24 - 52:34 (08:10)
Summary
This podcast discusses the challenges of collecting and sharing health data at a large scale to better understand how to detect pathogens and characteristics of the human body. The speaker also shares their experience with using consumer health data and breaks down the privacy and regulatory concerns surrounding this issue.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The speaker highlights the value of user control over personal data and suggests the need for policy creation, allowing individuals to share or delete their data as they deem appropriate, with a focus on providing transparency to the consumer.
52:34 - 1:00:56 (08:22)
Summary
The speaker highlights the value of user control over personal data and suggests the need for policy creation, allowing individuals to share or delete their data as they deem appropriate, with a focus on providing transparency to the consumer.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
In this episode, the hosts explore different diets and approaches to calorie restriction, including overeating on healthy foods and exercise, with a focus on finding what works best for each individual.
1:00:56 - 1:11:44 (10:47)
Summary
In this episode, the hosts explore different diets and approaches to calorie restriction, including overeating on healthy foods and exercise, with a focus on finding what works best for each individual.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The speaker discusses how listening to brown noise helps him feel better and zooms in his mind, prompting him to wish he tried it sooner.
1:11:44 - 1:17:36 (05:51)
Summary
The speaker discusses how listening to brown noise helps him feel better and zooms in his mind, prompting him to wish he tried it sooner.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
Disrupting our sleep-wake cycle and not getting enough deep sleep affects our health and memory.
1:17:36 - 1:23:23 (05:46)
Summary
Disrupting our sleep-wake cycle and not getting enough deep sleep affects our health and memory. Proteins in our body control our sleep-wake cycle and it is said that power naps can also make us feel rested.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The mind has an important role to play in determining longevity.
1:23:23 - 1:29:03 (05:40)
Summary
The mind has an important role to play in determining longevity. Stress and happiness are two factors that can impact the mind and have a direct effect on how long we live.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The earlier you start living a healthy lifestyle, the greater the benefits.
1:29:03 - 1:34:37 (05:34)
Summary
The earlier you start living a healthy lifestyle, the greater the benefits. Eating a healthy diet, skipping meals and starting at 25 years old all contribute to a long life.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
The most promising way to preserve the brain is by recording and rebuilding it through detailed scans.
1:34:37 - 1:40:16 (05:38)
Summary
The most promising way to preserve the brain is by recording and rebuilding it through detailed scans. Furthermore, efforts like Neuralink are working on creating brain computer interfaces to understand and enhance communication with the brain.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
We are evolved to want to live longer, but obsessing with longevity can hinder progress and enjoyment of the present.
1:40:16 - 1:48:43 (08:27)
Summary
We are evolved to want to live longer, but obsessing with longevity can hinder progress and enjoyment of the present. Regardless of how long we live, we are wondrous and unique beings in the universe.
Episode#189 – David Sinclair: Extending the Human Lifespan Beyond 100 Years
PodcastLex Fridman Podcast
In this podcast episode, Lex Fridman interviews David Sinclair about his work on aging and longevity, including the biology of aging, research into the effects of NAD, and lifestyle habits that can increase lifespan.
1:48:43 - 1:49:51 (01:07)
Summary
In this podcast episode, Lex Fridman interviews David Sinclair about his work on aging and longevity, including the biology of aging, research into the effects of NAD, and lifestyle habits that can increase lifespan.