Episode
Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
2:59:06
Published: Mon Apr 11 2022
Description
My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization (00:03:28) Sponsors: AG1, LMNT, Thesis, Momentous (00:08:24) Preventative Medicine & Hormone Health (00:14:17) The Six Pillars of Hormone Health Optimization (00:17:14) Diet for Hormone Health, Blood Testing (00:20:21) Exercise for Hormone Health (00:21:06) Caloric Restriction, Obesity & Testosterone (00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1 (00:29:08) Sleep Quality & Hormones (00:35:03) Testosterone in Women (00:38:55) Dihydrotestosterone (DHT), Hair Loss (00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine (00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto (00:52:30) Hair loss, DHT, Creatine Monohydrate (00:55:07) Hair Regrowth, Male Pattern Baldness (00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM (01:04:00) Oral Contraception, Perceived Attractiveness, Fertility (01:10:31) Testosterone & Marijuana or Alcohol (01:14:27) Sleep Supplement Frequency (01:15:34) Testosterone Supplementation & Prostate Cancer (01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein (01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil (01:30:54) Testosterone Replacement Therapy (TRT) (01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM (01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats (01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone (01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels (01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency (01:56:44) Boron, Sex Hormone Binding Globulin (SHBG) (01:58:13) Human Chorionic Gonadotropin (hCG), Fertility (02:04:18) Prolactin & Dopamine, Pituitary Damage (02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P) (02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic) (02:18:19) Blood Test Frequency (02:19:41) Long-Term Relationships & Effects on Hormones (02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships (02:29:05) Cold & Hot Exposure, Hormones & Fertility (02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin (02:37:24) Growth Hormone-Releasing Peptides (GHRPs) (02:39:38) BPC-157 & Injury, Dosing Frequency (02:45:23) Uses for Melanotan (02:48:21) Spiritual Health Impact on Mental & Physical Health (02:54:18) Caffeine & Hormones (02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Supplements, Instagram, Twitter Title Card Photo Credit: Mike Blabac Disclaimer
Chapters
Dr. Stephen Gillette shares his expertise on hormone health and optimization, including lifestyle, nutrition, exercise, and supplementation recommendations based on blood test results from InsideTracker.
00:00 - 07:46 (07:46)
Summary
Dr. Stephen Gillette shares his expertise on hormone health and optimization, including lifestyle, nutrition, exercise, and supplementation recommendations based on blood test results from InsideTracker.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
Dr. Kyle Gillette talks about the important role of understanding hormone health for both men and women.
07:46 - 14:38 (06:51)
Summary
Dr. Kyle Gillette talks about the important role of understanding hormone health for both men and women. He emphasizes its significance in achieving overall health and wellness.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The podcast discusses the significance of spiritual and physical health, with emphasis on a healthy diet, for better optimization of the body’s wellness.
14:38 - 20:50 (06:11)
Summary
The podcast discusses the significance of spiritual and physical health, with emphasis on a healthy diet, for better optimization of the body’s wellness.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
Intermittent fasting and saunas can increase growth hormone levels, but there is no evidence supporting that these natural methods can cause cancer.
20:50 - 29:14 (08:24)
Summary
Intermittent fasting and saunas can increase growth hormone levels, but there is no evidence supporting that these natural methods can cause cancer. Many people practice intermittent fasting for mental clarity and overall health benefits.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
This podcast episode highlights the misconceptions surrounding testosterone in women, including its roles, where it comes from, its replacement therapy, and how it affects sleep and stress levels.
29:14 - 38:19 (09:04)
Summary
This podcast episode highlights the misconceptions surrounding testosterone in women, including its roles, where it comes from, its replacement therapy, and how it affects sleep and stress levels.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
Androgens such as DHEA, testosterone, and DHT can bind to the androgen receptor in both men and women, leading to cardiac remodeling.
38:19 - 47:10 (08:51)
Summary
Androgens such as DHEA, testosterone, and DHT can bind to the androgen receptor in both men and women, leading to cardiac remodeling. However, drugs like finasteride or dutasteride can inhibit this activity, improving heart health.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The article discusses the positive and negative effects of DHT on the body, and the supplements that can help or harm DHT levels such as turmeric and creatine.
47:10 - 54:07 (06:56)
Summary
The article discusses the positive and negative effects of DHT on the body, and the supplements that can help or harm DHT levels such as turmeric and creatine. It also mentions that individuals with low DHT or sensitive androgen receptors should avoid bioavailable curcuminoids like bioavailable turmeric and black pepper extract, and may benefit from creatine.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The use of injections to decrease the conversion of testosterone to DHT in the scalp is a localized approach to treating male/female pattern baldness while avoiding prostate effects, and taking oral contraceptives can affect the perception of men’s attractiveness in women due to a blunting of hormonal output peaks and valleys.
54:07 - 1:06:06 (11:59)
Summary
The use of injections to decrease the conversion of testosterone to DHT in the scalp is a localized approach to treating male/female pattern baldness while avoiding prostate effects, and taking oral contraceptives can affect the perception of men’s attractiveness in women due to a blunting of hormonal output peaks and valleys.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The harmful effects of low alcohol intake on the brain are still being studied, as even low-intake can decrease brain volume.
1:06:06 - 1:17:06 (10:59)
Summary
The harmful effects of low alcohol intake on the brain are still being studied, as even low-intake can decrease brain volume. However, the consequences of this decrease in volume are still unknown.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The claim that testosterone makes prostate health worse is not entirely accurate as young males have high testosterone, yet do not suffer from prostate overgrowth or cancer.
1:17:06 - 1:26:53 (09:47)
Summary
The claim that testosterone makes prostate health worse is not entirely accurate as young males have high testosterone, yet do not suffer from prostate overgrowth or cancer. While normal aging causes prostate cancer, testosterone will increase the growth of existing prostate cancer.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
Low-dose Tadalafil is being used by men to improve long-term prostate health while medications such as finasteride are taken to decrease enlargement, and some men are opting for testosterone replacement therapy despite having adequate levels.
1:26:53 - 1:36:50 (09:57)
Summary
Low-dose Tadalafil is being used by men to improve long-term prostate health while medications such as finasteride are taken to decrease enlargement, and some men are opting for testosterone replacement therapy despite having adequate levels.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The discussion focuses on sports TRT or taking exogenous testosterone even though one doesn't need it, and the importance of fat, particularly saturated fat, and cholesterol in the synthesis of hormones.
1:36:50 - 1:43:54 (07:04)
Summary
The discussion focuses on sports TRT or taking exogenous testosterone even though one doesn't need it, and the importance of fat, particularly saturated fat, and cholesterol in the synthesis of hormones. The conversation also highlights the use of HCG in enhancing testosterone levels.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The ratio of testosterone to estrogen affects the activity of receptors in the body.
1:43:54 - 1:48:58 (05:03)
Summary
The ratio of testosterone to estrogen affects the activity of receptors in the body. Proper amounts of trans fats from ruminants and omega-3s are important in maintaining this ratio and avoiding potential problems associated with increased estrogen activity such as reduced libido and water retention.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The Nigerian shrub extract, Fadozia agrestis, has potential to increase testosterone and other hormones by stimulating luteinizing hormone release in the testes, but more evidence is needed to determine its safety for long-term use.
1:48:58 - 1:57:40 (08:41)
Summary
The Nigerian shrub extract, Fadozia agrestis, has potential to increase testosterone and other hormones by stimulating luteinizing hormone release in the testes, but more evidence is needed to determine its safety for long-term use. It can be cycled with Tonga Ali, and combined with naltrexone to increase LH in people recovering from opiates or alcohol.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
In this podcast, the conversation ranges from eating dirt to the use of boron for lowering SHBG.
1:57:40 - 2:01:53 (04:13)
Summary
In this podcast, the conversation ranges from eating dirt to the use of boron for lowering SHBG. The discussion covers how long-term use of boron can affect endogenous hormone output.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
This podcast episode explores the relationship between dopamine and prolactin, and how imbalances in these hormones can affect sexual behaviors.
2:01:53 - 2:09:56 (08:02)
Summary
This podcast episode explores the relationship between dopamine and prolactin, and how imbalances in these hormones can affect sexual behaviors. The role of pituitary adenomas in causing hormonal imbalances is also discussed.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
L-Carnitine has been shown to enhance sperm and egg quality, as well as improve rates of conception.
2:09:56 - 2:18:59 (09:03)
Summary
L-Carnitine has been shown to enhance sperm and egg quality, as well as improve rates of conception. However, it's important to note that not all forms of L-Carnitine are bioavailable when taken as a supplement.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The levels of hormones like dopamine and prolactin can affect the excitement and attachment in a relationship.
2:18:59 - 2:28:04 (09:04)
Summary
The levels of hormones like dopamine and prolactin can affect the excitement and attachment in a relationship. Blood tests to know hormone levels in different age groups can be useful to understand the impact on the relationship.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
Cold exposure such as ice baths or cold showers can increase testosterone and estrogen levels, but it will not correct underlying issues such as vitamin D deficiency or metabolic syndromes.
2:28:04 - 2:33:01 (04:57)
Summary
Cold exposure such as ice baths or cold showers can increase testosterone and estrogen levels, but it will not correct underlying issues such as vitamin D deficiency or metabolic syndromes. However, it may acutely benefit those with hypogonadism or varicoceles by applying cold specifically to warm testes.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The use of growth hormone releasing hormone peptides like sermoraline can increase growth hormone levels but may paradoxically result in low IGF-1 and similar cancer risks to type 1 diabetics with high risk.
2:33:01 - 2:40:17 (07:15)
Summary
The use of growth hormone releasing hormone peptides like sermoraline can increase growth hormone levels but may paradoxically result in low IGF-1 and similar cancer risks to type 1 diabetics with high risk. Peptides come in different sizes and there are many types worth learning more about.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
GHK Copper Peptide can help increase blood flow to injured areas and significantly aid the nervous system.
2:40:17 - 2:47:21 (07:04)
Summary
GHK Copper Peptide can help increase blood flow to injured areas and significantly aid the nervous system. It is also synergistic and helps replenish copper deficiency in the body.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
In this conversation, the speaker emphasizes the significance of maintaining a balance between physical, mental, and spiritual health as the cornerstone of overall well-being.
2:47:22 - 2:55:01 (07:39)
Summary
In this conversation, the speaker emphasizes the significance of maintaining a balance between physical, mental, and spiritual health as the cornerstone of overall well-being. The speaker also discusses the relevance of being cautious of the relative contraindications while choosing treatments for any symptom.
EpisodeDr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
PodcastHuberman Lab
The speaker encourages leaving comments and suggestions for the Huberman Lab podcast, and mentions the effect of caffeine on hormones before advertising supplements on livemomentous.com.
2:55:01 - 2:58:56 (03:54)
Summary
The speaker encourages leaving comments and suggestions for the Huberman Lab podcast, and mentions the effect of caffeine on hormones before advertising supplements on livemomentous.com.