Episode
#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
3:07:06
Published: Tue Nov 03 2015
Description
Dr. Dominic “Dom" D’Agostino (@DominicDAgosti2) is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast. He’s a beast and — no big surprise — he’s a good buddy of Dr. Peter Attia, my MD friend who drinks "jet fuel" in search of optimal athletic performance. The primary focus of Dom's laboratory is developing and testing metabolic therapies, including ketogenic diets, ketone esters and ketone supplements to induce nutritional/therapeutic ketosis. D’Agostino’s laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies and nutritional strategies for peak performance and resilience. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by Audible. I have used Audible for years and I love audio books. I have 2 to recommend: The Graveyard Book by Niel Gaiman Vagabonding by Rolf Potts All you need to do to get your free audiobook and a free 30-day trial is go to Audible.com/tim. Choose one of the above books, or choose between more than 180,000 audio programs. That could be a book, a newspaper, a magazine or even a class. It's that easy. Go to Audible.com/Tim and get started today. Enjoy! This podcast is also brought to you by 99Designs, the world’s largest marketplace of graphic designers. I have used them for years to create some amazing designs. When your business needs a logo, website design, business card, or anything you can imagine, check out 99Designs. I used them to rapid prototype the cover for The 4-Hour Body, and I've also had them help with display advertising and illustrations. If you want a more personalized approach, I recommend their 1-on-1 service, which is non-spec. You get original designs from designers around the world. The best part? You provide your feedback, and then you end up with a product that you're happy with or your money back. Click this link and get a free $99 upgrade. Give it a test run… Enjoy!***If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Interested in sponsoring the podcast? Visit tim.blog/sponsor and fill out the form.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Chapters
This transcript is a collection of unrelated phrases that do not form a coherent conversation or narrative.
00:00 - 00:34 (00:34)
Summary
This transcript is a collection of unrelated phrases that do not form a coherent conversation or narrative.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Tim Ferriss' Friday newsletter features five bullet points of cool things found during the week, including apps, books, supplements, and more.
00:35 - 07:58 (07:23)
Summary
Tim Ferriss' Friday newsletter features five bullet points of cool things found during the week, including apps, books, supplements, and more. Currently, the newsletter includes an offer from Athletic Greens for a free vitamin D supplement and travel packs with the first subscription purchase.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The committee responsible for reviewing studies on animal caloric restriction have a reactionary response if the animals lose more than 25% of their weight.
08:02 - 13:45 (05:43)
Summary
The committee responsible for reviewing studies on animal caloric restriction have a reactionary response if the animals lose more than 25% of their weight. The committee reviews the methodology, ethics, and purpose of the proposed study before approving its conduct.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Age and lifestyle factors affect the efficacy of the ketogenic diet.
13:45 - 24:02 (10:17)
Summary
Age and lifestyle factors affect the efficacy of the ketogenic diet. Advanced lifters may require a different approach with a higher protein intake for optimal results.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The host asks the guest about the implications of fasting, nutritional ketosis, or exogenous ketones for preventing Alzheimer's or Parkinson's disease, given that beta hydroxybutyrate can affect gene expression.
24:02 - 30:58 (06:55)
Summary
The host asks the guest about the implications of fasting, nutritional ketosis, or exogenous ketones for preventing Alzheimer's or Parkinson's disease, given that beta hydroxybutyrate can affect gene expression. The guest explains that there have been some promising results in animal studies, but more research needs to be done.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Catechia in cancer patients leads to the loss of lean body mass due to factors like TNF alpha and cytokines.
30:58 - 37:44 (06:46)
Summary
Catechia in cancer patients leads to the loss of lean body mass due to factors like TNF alpha and cytokines. The loss of lean body mass is compounded with the pathology of chemo-induced catechia and increases mortality rates.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
SARMs have the advantage of not carrying the stigma associated with anabolic steroids, making them a more politically acceptable option.
37:44 - 48:15 (10:31)
Summary
SARMs have the advantage of not carrying the stigma associated with anabolic steroids, making them a more politically acceptable option. It is possible to mimic the benefits of fasting pre-chemotherapy with exogenous ketones without increasing systemic IGF one levels.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Maintaining a physiologic range of ketones can have benefits for health, longevity, and performance; however, it is unclear if exogenous ketones can accelerate the induction of ketone production or if they only temporarily spike ketone readings.
48:15 - 54:15 (05:59)
Summary
Maintaining a physiologic range of ketones can have benefits for health, longevity, and performance; however, it is unclear if exogenous ketones can accelerate the induction of ketone production or if they only temporarily spike ketone readings.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Researchers are developing a pill version of a ketogenic diet that would release ketones in a slow and predictable manner, allowing people to achieve a level of ketosis that typically takes several days of fasting in as little as 15 minutes.
54:15 - 1:04:21 (10:05)
Summary
Researchers are developing a pill version of a ketogenic diet that would release ketones in a slow and predictable manner, allowing people to achieve a level of ketosis that typically takes several days of fasting in as little as 15 minutes. Two-thirds of kids who have failed all standard seizure control methods saw success with a ketogenic diet.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The statistical power of a study is crucial in determining the likelihood of detecting an effect, which requires consultation with a statistician.
1:04:21 - 1:10:36 (06:15)
Summary
The statistical power of a study is crucial in determining the likelihood of detecting an effect, which requires consultation with a statistician. While the sample size is important, it is not the sole determining factor in evaluating the statistical significance of a study.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The speaker found that by calming his body and being in a state of nutritional ketosis, he was able to increase his breath hold time by 300%.
1:10:36 - 1:17:55 (07:19)
Summary
The speaker found that by calming his body and being in a state of nutritional ketosis, he was able to increase his breath hold time by 300%. In animal models, transitioning to a ketogenic diet for four weeks also doubled protein levels and increased subunits of the transporter by 50%.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Researchers are working to develop palatable ketone salt products that can put an individual in mild ketosis range without having to worry about carbohydrate restriction or fasting, as some of these products taste good enough to look forward to tasting.
1:17:55 - 1:26:40 (08:44)
Summary
Researchers are working to develop palatable ketone salt products that can put an individual in mild ketosis range without having to worry about carbohydrate restriction or fasting, as some of these products taste good enough to look forward to tasting. In the meantime, some people, like the speaker, are consuming sardines packed in olive oil to obtain essential nutrients while maintaining a low-carb or nearly ketogenic diet.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The podcast discusses why glutamine is important in cancer treatment, as well as how the body uses it in response to challenging situations like chemotherapy, burns, and more.
1:26:40 - 1:36:42 (10:02)
Summary
The podcast discusses why glutamine is important in cancer treatment, as well as how the body uses it in response to challenging situations like chemotherapy, burns, and more.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Metformin, a drug commonly used to treat diabetes, has been found to have preventative properties in cancer growth.
1:36:42 - 1:43:01 (06:18)
Summary
Metformin, a drug commonly used to treat diabetes, has been found to have preventative properties in cancer growth. Many individuals take it prophylactically to lower their risk of cancer even if they are otherwise healthy.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The speaker discusses the importance of using the correct cancer cell models for research and emphasizes the necessity of standard of care for certain cancers such as testicular cancer, leukemia, and lymphoma.
1:43:01 - 1:50:43 (07:41)
Summary
The speaker discusses the importance of using the correct cancer cell models for research and emphasizes the necessity of standard of care for certain cancers such as testicular cancer, leukemia, and lymphoma.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Studies have found that activating the mitochondria of cancer cells, which have defective mitochondria, can cause them to trigger apoptosis.
1:50:43 - 2:00:04 (09:20)
Summary
Studies have found that activating the mitochondria of cancer cells, which have defective mitochondria, can cause them to trigger apoptosis. The use of exogenous ketones to boost energy may also be beneficial, especially for those with glioblastoma.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Fasting puts metabolic stress on cancer cells that are highly dependent on glucose and insulin, potentially triggering the death of pre-cancerous cells if done regularly once or twice a year, or even once a week.
2:00:04 - 2:06:30 (06:26)
Summary
Fasting puts metabolic stress on cancer cells that are highly dependent on glucose and insulin, potentially triggering the death of pre-cancerous cells if done regularly once or twice a year, or even once a week. You may experience some side effects, but the benefits could be worth it.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The ketogenic diet can enhance productivity by saving time and energy that goes into food preparation and consumption.
2:06:30 - 2:15:36 (09:05)
Summary
The ketogenic diet can enhance productivity by saving time and energy that goes into food preparation and consumption. Moreover, the diet can improve brain metabolic activity and restore the brain's homeostasis in seizure patients.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Short-chain fatty acids, formed from the breakdown of soluble fiber, contribute to ketogenesis and the generation of butyrate in the gut.
2:15:36 - 2:27:25 (11:49)
Summary
Short-chain fatty acids, formed from the breakdown of soluble fiber, contribute to ketogenesis and the generation of butyrate in the gut. By adding certain types of fiber, one could formulate a ketogenic diet with the intention to further enhance ketosis.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Mixing your protein with high fat and fiber, such as adding a chicken breast to a green leafy salad, can help you stay in ketosis.
2:27:25 - 2:35:07 (07:42)
Summary
Mixing your protein with high fat and fiber, such as adding a chicken breast to a green leafy salad, can help you stay in ketosis. Eating green leafy vegetables like spinach, kale, broccoli, and asparagus with a source of fat is also recommended to avoid excess amino acids and insulin release that can kick you out of ketosis.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The speaker shares their nighttime meal routine which consists of mixed greens, wild blueberries, and a protein-rich vegetable like collard greens or asparagus, cooked in lots of healthy oils.
2:35:07 - 2:43:03 (07:55)
Summary
The speaker shares their nighttime meal routine which consists of mixed greens, wild blueberries, and a protein-rich vegetable like collard greens or asparagus, cooked in lots of healthy oils.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The speaker gave a book about the ketogenic diet for cancer to his friends and years later, two of them contacted him and mentioned that the book inspired them to create a website called ketonutrition.org compiling useful links and materials.
2:43:03 - 2:47:55 (04:52)
Summary
The speaker gave a book about the ketogenic diet for cancer to his friends and years later, two of them contacted him and mentioned that the book inspired them to create a website called ketonutrition.org compiling useful links and materials.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The ketogenic diet could potentially lessen the impact of Lyme disease by reducing the inflammation and encephalopathy that it can cause, as well as potentially bringing the nervous system back to a state of homeostasis.
2:47:55 - 3:00:42 (12:46)
Summary
The ketogenic diet could potentially lessen the impact of Lyme disease by reducing the inflammation and encephalopathy that it can cause, as well as potentially bringing the nervous system back to a state of homeostasis. This is due to the anti-inflammatory effects of ketones, which can efficiently run the central nervous system in a state of ketosis, while also reducing the neurotoxic effects of Lyme disease.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
The host and guest discuss how fans can contact and find guests on various online platforms.
3:00:42 - 3:06:13 (05:30)
Summary
The host and guest discuss how fans can contact and find guests on various online platforms. The guest also promotes his weekly email list, Five Bullet Friday.
Episode#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer
PodcastThe Tim Ferriss Show
Tim Ferriss recommends two books, which includes Neil Gaiman’s The Graveyard Book and Rolf Potts’s Vagabonding, and encourages listeners to visit audible.com/tim for a free audio book and a 30-day trial.
3:06:13 - 3:07:00 (00:47)
Summary
Tim Ferriss recommends two books, which includes Neil Gaiman’s The Graveyard Book and Rolf Potts’s Vagabonding, and encourages listeners to visit audible.com/tim for a free audio book and a 30-day trial.